June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Assessment of Macular Perfusion in Multiple Evanescent White Dot Syndrome Using Optical Coherence Tomography Angiography
Author Affiliations & Notes
  • Abtin Shahlaee
    Retina Service, Wills Eye Hospital, Philadelphia, Pennsylvania, United States
  • Jayanth Sridhar
    Retina, Bascom Palmer Eye Institute, Miami, Florida, United States
    Retina Service, Wills Eye Hospital, Philadelphia, Pennsylvania, United States
  • Nika Bagheri
    Retina, Bascom Palmer Eye Institute, Miami, Florida, United States
    Retina Service, Wills Eye Hospital, Philadelphia, Pennsylvania, United States
  • Wasim Samara
    Retina Service, Wills Eye Hospital, Philadelphia, Pennsylvania, United States
  • James P Dunn
    Retina Service, Wills Eye Hospital, Philadelphia, Pennsylvania, United States
  • Sonia Mehta
    Retina Service, Wills Eye Hospital, Philadelphia, Pennsylvania, United States
  • Footnotes
    Commercial Relationships   Abtin Shahlaee, None; Jayanth Sridhar, None; Nika Bagheri, None; Wasim Samara, None; James Dunn, None; Sonia Mehta, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 1682. doi:
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      Abtin Shahlaee, Jayanth Sridhar, Nika Bagheri, Wasim Samara, James P Dunn, Sonia Mehta; Assessment of Macular Perfusion in Multiple Evanescent White Dot Syndrome Using Optical Coherence Tomography Angiography. Invest. Ophthalmol. Vis. Sci. 2017;58(8):1682.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Optical coherence tomography angiography (OCT-A) enables non-invasive depth-resolved evaluation of macular perfusion.This study aims to assess macular blood flow across various retinal and choroidal layers in the setting of multiple evanescent white dot syndrome (MEWDS).

Methods : Consecutive case series with comparison of affected eyes to fellow eyes using OCT-A (RTVue-XR Avanti, Optovue) measured macular vascular density.

Results : Five eyes with MEWDS and 5 fellow eyes were examined. The mean overall macular vascular density was lower in eyes with MEWDS compared to fellow eyes in both the deep capillary plexus (58.9% versus 61.5%, respectively; P=0.042) and choriocapillaris (66.5% versus 68.3%, respectively; P=0.043). The mean overall vascular density was similar in the superficial capillary plexus (54.0% versus 55.1%, respectively; p=0.500).

Conclusions : Quantitative OCT-A measurements non-invasively demonstrated significantly reduced deep capillary plexus and choriocapillaris perfusion in eyes with MEWDS when compared to fellow eyes. This offers further insight into the potential pathophysiologic processes involved in this disorder.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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