June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Optical Coherence Tomography Angiography in Serpiginous Choroiditis
Author Affiliations & Notes
  • Daniela Montorio
    Department of Ophthalmology, IRCCS San Raffaele Scientific Institute, University Vita-Salute San Raffaele, Milan, Italy, Milan, Italy
    Eye Clinic, Department of Neurosciences, Reproductive Sciences and Dentistry., University of Naples Federico II, Napoli, Italy
  • Elisabetta Miserocchi
    Department of Ophthalmology, IRCCS San Raffaele Scientific Institute, University Vita-Salute San Raffaele, Milan, Italy, Milan, Italy
  • Giulio Modorati
    Department of Ophthalmology, IRCCS San Raffaele Scientific Institute, University Vita-Salute San Raffaele, Milan, Italy, Milan, Italy
  • Stefano Mercuri
    Department of Ophthalmology, IRCCS San Raffaele Scientific Institute, University Vita-Salute San Raffaele, Milan, Italy, Milan, Italy
  • Alessandro Rabiolo
    Department of Ophthalmology, IRCCS San Raffaele Scientific Institute, University Vita-Salute San Raffaele, Milan, Italy, Milan, Italy
  • Riccardo Sacconi
    Department of Ophthalmology, IRCCS San Raffaele Scientific Institute, University Vita-Salute San Raffaele, Milan, Italy, Milan, Italy
    Department of Ophthalmology, University of Verona, University hospital of Verona, Verona, Italy., Verona, Italy
  • Adriano Carnevali
    Department of Ophthalmology, IRCCS San Raffaele Scientific Institute, University Vita-Salute San Raffaele, Milan, Italy, Milan, Italy
    Department of Ophthalmology, University of "Magna Graecia", Catanzaro, Italy., Catanzaro, Italy
  • Lea Querques
    Department of Ophthalmology, IRCCS San Raffaele Scientific Institute, University Vita-Salute San Raffaele, Milan, Italy, Milan, Italy
  • Giuseppe Querques
    Department of Ophthalmology, IRCCS San Raffaele Scientific Institute, University Vita-Salute San Raffaele, Milan, Italy, Milan, Italy
  • Francesco Bandello
    Department of Ophthalmology, IRCCS San Raffaele Scientific Institute, University Vita-Salute San Raffaele, Milan, Italy, Milan, Italy
  • Footnotes
    Commercial Relationships   Daniela Montorio, None; Elisabetta Miserocchi, None; Giulio Modorati, None; Stefano Mercuri, None; Alessandro Rabiolo, None; Riccardo Sacconi, None; Adriano Carnevali, None; Lea Querques, None; Giuseppe Querques, Alimera Sciences (C), Allergan Inc (C), Bayer Shering-Pharma (C), Heidelberg (C), Novartis (C), Zeiss (C); Francesco Bandello, Alcon (C), Alimera Sciences (C), Allergan Inc (C), Bausch and Lomb (C), Bayer Shering-Pharma (C), Farmila-Thea (C), Genentech (C), Hoffmann-La Roche (C), NovagaliPharma (C), Novartis (C), Sanofi-Aventis (C), Thrombogenetics (C), Zeiss (C)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 1687. doi:
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      Daniela Montorio, Elisabetta Miserocchi, Giulio Modorati, Stefano Mercuri, Alessandro Rabiolo, Riccardo Sacconi, Adriano Carnevali, Lea Querques, Giuseppe Querques, Francesco Bandello; Optical Coherence Tomography Angiography in Serpiginous Choroiditis. Invest. Ophthalmol. Vis. Sci. 2017;58(8):1687.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To analyze vessel density of the whole choroid in Serpiginous Choroiditis (SC) using optical coherence tomography angiography (OCT-A).

Methods : Observational study. Nineteen eyes of 11 patients affected by Serpiginous Choroiditis were recruited. All patients underwent SD-OCT (Spectralis Heidelberg Retinal Angiograph + OCT; Heidelberg Engineering, Heidelberg, Germany) and OCT-A (AngioPlex Elite 9000 SS-OCT, Carl Zeiss Meditech, Inc., Dublin, USA). Quantification of vessel density of whole choroid was performed by means analysis of binarized 6x6 mm OCT-A images. Four different regions of the retina were chosen for investigation: unaffected area, inner border of the lesion, outer border of the lesion and affected retina. Border regions were defined as portion of retina within 30 µm from the dividing limit between affected and unaffected area.

Results : Nineteen eyes of 11 Caucasian patients (3 males, 27.3%), with a mean age of 60.72 years ± 6.80 were enrolled. The whole choroid showed statistically significant reduction of vessel density in affected areas (0.235 ± 0.13) compared to unaffected areas (0.756 ± 0.14) (p <0.001), and between inner borders(0.330 ± 0.13) and outer borders (0.659 ± 0.13) of affected areas (p <0.001).
Statistically significant differences in vessel density were detected between affected areas (0.235 ± 0.13) and inner borders (0.330 ± 0.13) (p=0.035) and between unaffected areas (0.756 ± 0.14) and outer borders of the lesion (0.659 ± 0.13) (p=0.038). Also the differences between affected areas (0.235 ± 0.13) and outer borders (0.659 ± 0.13), between unaffected areas (0.756 ± 0.14) and inner borders (0.330 ± 0.13) were statistically significant (p<0.001).

Conclusions : OCT-A demonstrated progressive loss of the whole choroid from the inner border of affected areas to unaffected areas in eyes with Serpiginous Choroiditis.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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