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Joshua Nunn, Shruti Sudhakar, Ingrid U Scott, Seth Pantanelli; Omidria® versus Epinephrine: A Retrospective Review of Intraoperative Maintenance of Mydriasis. Invest. Ophthalmol. Vis. Sci. 2017;58(8):1829.
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© ARVO (1962-2015); The Authors (2016-present)
To compare the relative efficacy of phenylephrine 1.0%-ketorolac 0.3% (Omidria®) versus epinephrine in the maintenance of mydriasis during cataract surgery.
This study was approved by the local Institutional Review Board. Surgical videos of eyes that underwent cataract surgery with intraocular lens implantation at an academic medical center between 08/2015 and 06/2016 and which received intracameral Omidria® or epinephrine were reviewed retrospectively. A single examiner who was masked with respect to intracameral mydriatic agent administered reviewed each surgical video and measured the intraoperative pupil diameter at 1 minute intervals for the duration of the surgery. Preoperative white-to-white measurements were used as a reference to calculate pupil diameters.
The study included 46 eyes (19 Omidria®, 27 Epinephrine) from 46 patients. The two patient groups were similar with respect to age, gender, race, baseline intraocular pressure, white-to-white distance, axial length, use of tamsulosin, and baseline pupil diameter. There was no statistically significant difference in the mean area under the curve change from baseline pupil diameter between the two groups (0.85 versus 0.44, respectively; p = 0.7494). No eye in either group had a pupil diameter of less than 6 mm at any time during the procedure.
No significant differences were identified between Omidria® and epinephrine with regards to maintenance of intraoperative mydriasis. This finding warrants further investigation in prospective randomized studies with larger sample sizes.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
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