June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Incidence of Cystoid Macular Edema after Intracameral Vancomycin in Cataract Surgery
Author Affiliations & Notes
  • Mona Adeli
    Ophthalmology, The Ohio State University, Columbus, Ohio, United States
  • Thomas Mauger
    Ophthalmology, The Ohio State University, Columbus, Ohio, United States
  • Footnotes
    Commercial Relationships   Mona Adeli, None; Thomas Mauger, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 1831. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Mona Adeli, Thomas Mauger; Incidence of Cystoid Macular Edema after Intracameral Vancomycin in Cataract Surgery. Invest. Ophthalmol. Vis. Sci. 2017;58(8):1831.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : Various studies have demonstrated the efficacy of intracameral antibiotics in decreasing the incidence of endophthalmitis after cataract surgery. While many of the initial studies utilized intracameral cephalosporin agents, intracameral vancomycin has been used as an alternative in penicillin-allergic patients. The purpose of this study was to compare the incidence of pseudophakic cystoid macular edema (CME) in subjects who received intracameral cephalosporin versus intracameral vancomycin during cataract surgery.

Methods : A retrospective chart review was conducted on all subjects at our academic institution with the diagnosis of CME by ICD code between the time period of January 1, 2010 and June 30, 2015. Inclusion criterion was the documentation of CME within a 90-day post-operative period after cataract surgery. Exclusion criteria were prior history of macular edema, history of epiretinal membrane, concomitant vitreoretinal surgery at the time of cataract extraction, intraoperative posterior capsule tear, and history of diabetes mellitus. A Pearson’s chi-square test was used for statistical analysis.

Results : The final analysis included a total of 24 subjects (29 eyes) with CME. The incidence of pseudophakic CME in our population of 7,822 cataract surgeries after applying the above-stated exclusion criteria was 0.37%. The incidence of pseudophakic CME was 0.33% in subjects who received intracameral cephalosporin, and 0.78% in subjects who received intracameral vancomycin. There was no significant difference between the incidence of CME between these groups (p = 0.054).

Conclusions : This study demonstrated a trend toward a higher incidence of CME in subjects who received intracameral vancomycin as opposed to intracameral cephalosporin during cataract surgery. This finding was not, however, statistically significant. However, the morbidity associated with the development of CME is much lower than that associated with the development of endophthalmitis. Additional research must be conducted to determine the safest endophthalmitis prophylaxis in the population of penicillin- and cephalosporin-allergic patients.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×