June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Optical Coherence Tomography Angiography Features of Choroidal Neovascularization Associated with Choroidal Nevus
Author Affiliations & Notes
  • Federico Corvi
    Department of Biomedical and Clinical Science “Luigi Sacco”, Eye Clinic, Sacco Hospital, University of Milan, Milan, Italy
  • Marco Pellegrini
    Department of Biomedical and Clinical Science “Luigi Sacco”, Eye Clinic, Sacco Hospital, University of Milan, Milan, Italy
  • Emil Anthony T Say
    Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania, United States
  • Carol L Shields
    Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania, United States
  • Giovanni Staurenghi
    Department of Biomedical and Clinical Science “Luigi Sacco”, Eye Clinic, Sacco Hospital, University of Milan, Milan, Italy
  • Footnotes
    Commercial Relationships   Federico Corvi, None; Marco Pellegrini, Optovue (C); Emil Anthony Say, None; Carol Shields, None; Giovanni Staurenghi, Alcon (C), Alcon (R), Allergan (C), Bayer (C), Bayer (R), Boehringer Ingelheim (C), Genentech (C), Heidelberg Engineering (C), Heidelberg Engineering (R), Novartis (F), Novartis (C), Novartis (R), Ocular Instruments (P), Optos (C), Optovue (F), Roche (C), Zeiss (F), Zeiss (C)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 1854. doi:
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      Federico Corvi, Marco Pellegrini, Emil Anthony T Say, Carol L Shields, Giovanni Staurenghi; Optical Coherence Tomography Angiography Features of Choroidal Neovascularization Associated with Choroidal Nevus. Invest. Ophthalmol. Vis. Sci. 2017;58(8):1854.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To describe the imaging features of choroidal neovascularization (CNV) associated with choroidal nevus using optical coherence tomography angiography (OCT-A) imaging.

Methods : Retrospective observational case series. Patients with CNV secondary to choroidal nevus underwent full imaging examination including fundus photography, B-scan ultrasound, fluorescein angiography (FA), indocyanine green angiography (ICGA), spectral domain optical coherence tomography (SD-OCT), and OCT-A. The OCT-A features were analyzed and correlated with conventional angiography findings and SD-OCT. OCT-A was conducted using the split spectrum amplitude decorrelation angiography (SSADA) algorithm included in the Angiovue imaging system based on the commercially available Optovue RTVue XR Avanti (Optovue, Inc., Fremont, CA) in order to visualize blood flow and to allow a detailed evaluation of both retinal and choroidal circulations. We used a 6x6 protocol in order to have a comprehensive view of the affected area and a 3x3 to magnify and better characterize CNV details.

Results : There were 11 eyes from 11 patients (6 male and 5 female, mean age of 65±20.4 years) included in the analysis. FA and ICGA documented the abnormal vascular network in 90% and 83%, respectively. OCT-A displayed CNV network in 11 eyes (100%). The pattern was classified as “sea-fan” in 8 eyes (73%) and “long filamentous linear vessels” in 3 (27%). Distinct from CNV, intrinsic vasculature within the nevus was observed in 6 eyes (55%), corresponding to those with retinal pigment epithelium chronic changes.

Conclusions : OCT-A is a useful imaging technique to disclose CNV associated with choroidal nevus. Despite the presence of intraretinal or subretinal fluid and hemorrhage, OCT-A revealed the CNV in all cases. This imaging modality can be useful for analysis of long-standing nevi with related exudation.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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