June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Choroidal Thickness in Smokers Compared to Non-smokers by Enhanced Depth Imaging Optical Coherence Tomography
Author Affiliations & Notes
  • Jared James Murray
    University of Minnesota Medical School, Minneapolis, Minnesota, United States
  • Yao Wang
    Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, Minnesota, United States
  • Robert Joseph White
    University of Minnesota Medical School, Minneapolis, Minnesota, United States
  • Kevin Firl
    University of Minnesota Medical School, Minneapolis, Minnesota, United States
  • Tu Tran
    University of Minnesota Medical School, Minneapolis, Minnesota, United States
  • Alexander Feng
    University of Minnesota Medical School, Minneapolis, Minnesota, United States
  • Sandra Rocio Montezuma
    Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, Minnesota, United States
  • Footnotes
    Commercial Relationships   Jared Murray, None; Yao Wang, None; Robert White, None; Kevin Firl, None; Tu Tran, None; Alexander Feng, None; Sandra Montezuma, None
  • Footnotes
    Support  VitreoRetinal Surgery Foundation Research Award
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 1874. doi:
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      Jared James Murray, Yao Wang, Robert Joseph White, Kevin Firl, Tu Tran, Alexander Feng, Sandra Rocio Montezuma; Choroidal Thickness in Smokers Compared to Non-smokers by Enhanced Depth Imaging Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2017;58(8):1874.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To assess choroidal thickness in smokers and non-smokers using enhanced depth imaging spectral-domain optical coherence tomography (EDI-OCT).

Methods : This was a cross-sectional study conducted at the Minnesota State Fair from September 2nd - 4th, 2016. After basic ocular examination, EDI-OCT was used to measure subfoveal choroidal thickness, the distance from the hyper-reflective retinal pigment epithelium to the outer choroid under the fovea.

Results : 107 subjects (46 males, 61 females) with a mean age of 42 participated in this study. Smokers were defined as individuals with greater than one pack year of tobacco use. There were 54 smokers, which included both current and former smokers, and 53 non-smokers. After accounting for possible conounding variables (hypertension, diabetes, and myopia), no significant difference was found in choroidal thickness between smokers and non-smokers (300.8 and 283.9 μm, respectively; Student’s t-test, p=0.39). Additionally, among smokers, there was no statistically significant correlation between pack year history and choroidal thickness (Pearson correlation coefficient 0.024, p = 0.869). An inverse relationship between age and choroidal thickness was found (Pearson correlation coefficient = -0.393, p<0.001).

Conclusions : Prior studies have shown that nicotine can acutely reduce the choroidal thickness due to its vasoconstrictive effect. However, the long term effects of tobacco exposure on choroidal thickness are still not understood. This study did not identify statistically significant differences in choroidal thickness between smokers and non-smokers.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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