June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Reflectivity of the retinal cystoid space and visual outcome after intravitreal ranibizmab injection in diabetic macular edema
Author Affiliations & Notes
  • Norihiro Nagai
    Laboratory of Retinal Cell Biology, Keio University, School of Medicine, Tokyo, Japan
    Ophthalmology, Keio University, Tokyo, Japan
  • Misa Suzuki
    Laboratory of Retinal Cell Biology, Keio University, School of Medicine, Tokyo, Japan
    Ophthalmology, Keio University, Tokyo, Japan
  • Toshihide Kurihara
    Ophthalmology, Keio University, Tokyo, Japan
  • Mamoru Kamoshita
    Laboratory of Retinal Cell Biology, Keio University, School of Medicine, Tokyo, Japan
    Ophthalmology, Keio University, Tokyo, Japan
  • Hideki Sonobe
    Ophthalmology, Keio University, Tokyo, Japan
  • Sakiko Minami
    Ophthalmology, Keio University, Tokyo, Japan
  • Hajime Shinoda
    Ophthalmology, Keio University, Tokyo, Japan
  • Kazuo Tsubota
    Ophthalmology, Keio University, Tokyo, Japan
  • Yoko Ozawa
    Laboratory of Retinal Cell Biology, Keio University, School of Medicine, Tokyo, Japan
    Ophthalmology, Keio University, Tokyo, Japan
  • Footnotes
    Commercial Relationships   Norihiro Nagai, None; Misa Suzuki, None; Toshihide Kurihara, None; Mamoru Kamoshita, None; Hideki Sonobe, None; Sakiko Minami, None; Hajime Shinoda, None; Kazuo Tsubota, None; Yoko Ozawa, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 1902. doi:
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      Norihiro Nagai, Misa Suzuki, Toshihide Kurihara, Mamoru Kamoshita, Hideki Sonobe, Sakiko Minami, Hajime Shinoda, Kazuo Tsubota, Yoko Ozawa; Reflectivity of the retinal cystoid space and visual outcome after intravitreal ranibizmab injection in diabetic macular edema. Invest. Ophthalmol. Vis. Sci. 2017;58(8):1902.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To determine the association between reflectivity of the retinal cystoid space evaluated by optical coherence tomography (OCT) and visual outcome after intravitreal ranibizmab (IVR) monotherapy in diabetic macular edema (DME).

Methods : We reviewed clinical records of 24 eyes in 24 DME patients who received a single IVR and thereafter pro re nata (PRN) injections for 11 months. The reflectivity score of the retinal cystoid space in the horizontal OCT image including fovea was evaluated using ImageJ software comparing the reflectivity levels of vitreous (set as 0) and the nerve fiver layer (set as 100) at baseline. Transverse lengths of disrupted ellipsoid zone (EZ) in the OCT images were analyzed at baseline and 1 year after IVR treatment. Correlations between the baseline reflectivity, and the improvement in best corrected visual acuity (BCVA) or the disrupted EZ, at year 1 were statistically analyzed using multiple regression models.

Results : Baseline reflectivity of the retinal cystoid space was 0.03-43.6 (average16.9+13.2), and had a significant negative correlations with improvement in BCVA (P=0.04, 95% CI -0.02 to -0.0002) and improvement of EZ (P=0.04, -43.8 to -0.51).

Conclusions : Reflectivity of the retinal cystoid space at baseline may be a possible predictive factor for treatment outcome after IVR treatment in DME.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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