June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Nutritional Supplementation Inhibits the Increase in Serum Malondialdehyde in Patients with Wet Age-related Macular Degeneration
Author Affiliations & Notes
  • Kei Takayama
    Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
  • Toshiyuki Matsuura
    Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
  • Hiroki Kaneko
    Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
  • Hiroshi Fukukita
    Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
  • Keiko Kataoka
    Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
  • Yosuke Nagasaka
    Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
  • Taichi Tsunekawa
    Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
  • Yasuki Ito
    Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
  • Hiroko Terasaki
    Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
  • Footnotes
    Commercial Relationships   Kei Takayama, None; Toshiyuki Matsuura, None; Hiroki Kaneko, None; Hiroshi Fukukita, None; Keiko Kataoka, None; Yosuke Nagasaka, None; Taichi Tsunekawa, None; Yasuki Ito, None; Hiroko Terasaki, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 1947. doi:
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    • Get Citation

      Kei Takayama, Toshiyuki Matsuura, Hiroki Kaneko, Hiroshi Fukukita, Keiko Kataoka, Yosuke Nagasaka, Taichi Tsunekawa, Yasuki Ito, Hiroko Terasaki; Nutritional Supplementation Inhibits the Increase in Serum Malondialdehyde in Patients with Wet Age-related Macular Degeneration
      . Invest. Ophthalmol. Vis. Sci. 2017;58(8):1947.

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      © ARVO (1962-2015); The Authors (2016-present)

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  • Supplements
Abstract

Purpose : To compare serum levels of malondialdehyde (MDA) in patients with wet age-related macular degeneration (wAMD), patients with dry AMD (dAMD), and patients without AMD, and to evaluate the efficacy of nutritional supplementation for treating elevated serum MDA in patients with wAMD.

Methods : MDA levels were measured in sera from 20 patients with wAMD, 20 with dAMD, and 24 without AMD (mean age was 71.8 ± 11.0 years, 70.6 ± 12.5 years, 68.2 ± 10.2 years, respectively). Correlations between serum MDA levels and ages, visual acuity, or choroidal neovascular lesion area measured by fluorescein angiography images in eyes with wAMD / geographic atrophy area measured by fundus autofluorescence images in eyes with dAMD were analyzed. Patients with wAMD were randomized to receive or not receive nutritional supplementation (10 patients in each group), and MDA levels were measured after 3 months of treatment.

Results : MDA levels in patients with wAMD (9.94 ± 1.53 pmol/ml) were significantly greater compared with patients without AMD (9.04 ± 0.96 pmol/ml, P = 0.031). An increase in MDA was also observed in the dAMD group (9.30 ± 0.92 pmol/mL) compared with the control group, although the difference was not significant. In eyes with wAMD, there was a significant correlation between MDA levels and choroidal neovascularization lesion area (P = 0.038, r = 0.39). After 3 months of treatment, serum MDA levels in patients received supplementation decreased from 10.34 ± 2.03 pmol/ml at baseline to 8.88 ± 1.18 pmol/ml (P = 0.064) and significantly increased from 9.54 ± 0.70 pmol/ml at baseline to 10.41 ± 1.36 pmol/ml in those who did not (P = 0.012).

Conclusions : Baseline serum MDA levels were elevated in patients with wAMD, and MDA levels were directly correlated with choroidal neovascularization lesion area. In addition, nutritional supplementation appeared exert a protective effect against oxidative stress in patients with wAMD.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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