June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Association of the SIX1-SIX6 Locus with Primary Open-angle Glaucoma in Chinese and Japanese
Author Affiliations & Notes
  • Chi Pui Pang
    Ophthalmology & Visual Sciences, Chinese University of Hong Kong, Kowloon, Hong Kong
    Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong, Shantou, China
  • Shi Song Rong
    Ophthalmology & Visual Sciences, Chinese University of Hong Kong, Kowloon, Hong Kong
  • Christopher Kai-Shun Leung
    Ophthalmology & Visual Sciences, Chinese University of Hong Kong, Kowloon, Hong Kong
  • Noriyasu Hashida
    Department of Ophthalmology, Osaka University Medical School, Osaka, Japan
  • Pancy Oi Sin Tam
    Ophthalmology & Visual Sciences, Chinese University of Hong Kong, Kowloon, Hong Kong
  • Motokazu Tsujikawa
    Department of Ophthalmology, Osaka University Medical School, Osaka, Japan
  • Mingzhi Zhang
    Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong, Shantou, China
  • Kohji Nishida
    Department of Ophthalmology, Osaka University Medical School, Osaka, Japan
  • Li Jia Chen
    Ophthalmology & Visual Sciences, Chinese University of Hong Kong, Kowloon, Hong Kong
    Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong, Shantou, China
  • Footnotes
    Commercial Relationships   Chi Pui Pang, None; Shi Song Rong, None; Christopher Leung, None; Noriyasu Hashida, None; Pancy Oi Sin Tam, None; Motokazu Tsujikawa, None; Mingzhi Zhang, None; Kohji Nishida, None; Li Jia Chen, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 2132. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to Subscribers Only
      Sign In or Create an Account ×
    • Get Citation

      Chi Pui Pang, Shi Song Rong, Christopher Kai-Shun Leung, Noriyasu Hashida, Pancy Oi Sin Tam, Motokazu Tsujikawa, Mingzhi Zhang, Kohji Nishida, Li Jia Chen; Association of the SIX1-SIX6 Locus with Primary Open-angle Glaucoma in Chinese and Japanese. Invest. Ophthalmol. Vis. Sci. 2017;58(8):2132.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : To evaluate the association of the SIX1-SIX6 locus with primary open-angle glaucoma (POAG) in Chinese and Japanese.

Methods : Two Chinese cohorts from Hong Kong and Shantou, respectively, and one Japanese cohort from Osaka, totalling 2528 subjects (1223 POAG patients vs. 1305 controls) were recruited in this study. Thirteen single-nucleotide polymorphisms (SNPs), including 11 haplotype-tagging SNPs covering the entire SIX1-SIX6 locus and 2 SNPs from previous genome-wide association studies (GWAS, rs33912345 and rs10483727) were genotyped.

Results : In univariate association analysis, we identified a new SNP (rs12436579) to be associated with POAG (P=0.0064) in the Hong Kong cohort. One SNP reported by GWAS (rs33912345) showed a borderline association (P=0.067). In the replication analysis, these 2 SNPs were associated with POAG in the Shantou cohort (P<0.015), with the odds ratios (ORs) pointing to the same direction as that in the Hong Kong cohort. In the Osaka cohort, these 2 SNPs did not showed statistical significance (P>0.19), although their ORs were towards the same direction as that in the Hong Kong and Shantou cohorts. In the meta-analysis combining the 3 cohorts, the associations of these 2 SNPs were significant with low inter-cohort heterogeneities (rs33912345: Pmeta=0.0016, OR=0.78, I2=0; rs12436579: Pmeta=0.00075, OR=0.79, I2=10%).

Conclusions : This study confirmed the association of the SIX1-SIX6 locus with POAG in Chinese and Japanese, and identified a new tagging SNP (rs12436579) for POAG.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×