June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Health related quality of life in patients with Punctate Inner Choroidopathy (PIC)
Author Affiliations & Notes
  • Archana Pradeep
    Ophthalmology, University of Birmingham, Leicester, United Kingdom
  • sreekanth sreekantam
    Ophthalmology, University of Birmingham, Leicester, United Kingdom
  • Rob Carmichael
    Ophthalmology, University of Birmingham, Leicester, United Kingdom
  • Sarah Graves
    Ophthalmology, University of Birmingham, Leicester, United Kingdom
  • Sue Southworth
    Ophthalmology, University of Birmingham, Leicester, United Kingdom
  • Erika Damato
    Ophthalmology, University of Birmingham, Leicester, United Kingdom
  • Philip Ian Murray
    Ophthalmology, University of Birmingham, Leicester, United Kingdom
  • Alastair K Denniston
    Ophthalmology, University of Birmingham, Leicester, United Kingdom
  • Footnotes
    Commercial Relationships   Archana Pradeep, None; sreekanth sreekantam, None; Rob Carmichael, None; Sarah Graves, None; Sue Southworth, None; Erika Damato, None; Philip Murray, None; Alastair Denniston, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 2163. doi:
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    • Get Citation

      Archana Pradeep, sreekanth sreekantam, Rob Carmichael, Sarah Graves, Sue Southworth, Erika Damato, Philip Ian Murray, Alastair K Denniston; Health related quality of life in patients with Punctate Inner Choroidopathy (PIC). Invest. Ophthalmol. Vis. Sci. 2017;58(8):2163.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Punctate inner choroidopathy (PIC) is an uncommon, inflammatory multifocal chorioretinopathy affecting predominantly young myopic women characterized by the presence of multiple, yellow-white fundus lesions, in the absence of intraocular inflammation. Clinical course is highly variable with prognosis ranging from spontaneous recovery to bilateral sight loss. Quality of life (QoL)impact of this disease has not been investigated. Aim of our study was to evaluate the Health Related Quality of Life (HRQoL) measured using the European Quality of Life-5 Dimensions Questionnaire (EQ-5D).

Methods : 17 patients with PIC attending our supra-regional multidisciplinary clinic from May 2015 were included in this prospective observational study. QoL data was collected using EQ-5D questionnaire. EQ-5D a five-dimension instrument, and measures the influence of a health state on mobility, self-care, usual activities, pain/discomfort, and depression/anxiety. Each dimension is given one of three levels of severity.

Results : Median age of our patient cohort was 43.6 years with a female preponderance of 82.4% . 10/17 patients had visual acuity of less than 6/48 in either / both eyes. The median EQ5D index score was 0.837 (SD 0.15) and the median EQ5D Vas was 82 (SD19.5). 64.7% patients reported no problems with mobility and 88.2% had no difficulties with self- care. Over half of the patients (58.8%) reported some problems with usual activities. A similar proportion of patients reported some problems with anxiety/depression. Clinic staff noted that the questionnaire was frequently helpful in highlighting issues around health-related quality of life that were not picked up at any other point during the consultation.

Conclusions : This pilot study found EQ-5D to be relatively insensitive for visual disability in PIC, which is in line with studies in a number of other ophthalmic conditions. This study is now being extended in combination with the National Eye Institute Visual Function Questionnaire (NEI-VFQ)-25 to provide longitudinal assessments of the whole PIC cohort to detect of this sensitive over time to progression of disease and response to treatment.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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