June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Alternation of gut microbiota composition in patients with acute anterior uveitis
Author Affiliations & Notes
  • Xinyue Huang
    ophthalmology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
  • Zi Ye
    ophthalmology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
  • Aize Kijlstra
    University Eye Clinic Maastricht, Maastricht, Netherlands
  • Peizeng Yang
    ophthalmology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
  • Footnotes
    Commercial Relationships   Xinyue Huang, None; Zi Ye, None; Aize Kijlstra, None; Peizeng Yang, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 2166. doi:
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    • Get Citation

      Xinyue Huang, Zi Ye, Aize Kijlstra, Peizeng Yang; Alternation of gut microbiota composition in patients with acute anterior uveitis. Invest. Ophthalmol. Vis. Sci. 2017;58(8):2166.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To identified the characteristics of gut microbiota in patients with acute anterior uveitis.

Methods : Fecal DNA were extracted from 78 fecal samples (17 acute anterior uveitis (AAU) patients with ankylosing spondylitis (AS)(AAU+AS+ patients), 21 AAU patients without AS (AAU+AS- patients) and 40 sex- and gender matched healthy controls) and then sequencing by high-throughput 16S rRNA gene.

Results : There was a significant decrease in annotated species numbers and bacterial diversity between AAU+AS+ patients and healthy-controls.There was a significant distance as beta diversity between AAU+AS+ patients and healthy controls.A linear discriminant analysis of bacterial taxa showed that the abundance of Lachnospiracea_incertae_sedis, Blautia and Roseburia were significant decrease in AAU+AS- patients as compared with healthy controls.

Conclusions : Composition of gut microbiota in AAU patients was totally different from healthy controls.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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