June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
The relationship between uveitis in patients with arthritis and demographic and clinical characteristics: A population-based study.
Author Affiliations & Notes
  • Marta Mora
    UCSF, San Francisco, California, United States
  • Shan Lin
    UCSF, San Francisco, California, United States
  • Marisse Masis
    UCSF, San Francisco, California, United States
  • Travis C Porco
    UCSF, San Francisco, California, United States
  • Catherine Oldenburg
    UCSF, San Francisco, California, United States
  • Footnotes
    Commercial Relationships   Marta Mora, None; Shan Lin, None; Marisse Masis, None; Travis Porco, None; Catherine Oldenburg, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 2181. doi:
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      Marta Mora, Shan Lin, Marisse Masis, Travis C Porco, Catherine Oldenburg; The relationship between uveitis in patients with arthritis and demographic and clinical characteristics: A population-based study.. Invest. Ophthalmol. Vis. Sci. 2017;58(8):2181.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To assess the relationship between self-reported uveitis in patients with diagnosed arthritis and purported demographic and clinical risk factors, of a population extracted from the National Health and Nutrition Examination Survey (NHANES).

Methods : For our study we used the NHANES database of the Centers for Disease Control and Prevention (CDC) for the year 2009-2010. A national representative sample of 5,106 subjects diagnosed with arthritis, extracted from a pool of 10,537 patients, were asked if they had ever been diagnosed with uveitis. The demographic analysis included age, gender and ethnicity. The main outcome was the presence of uveitis. Potential predictors were type of arthritis, history of smoking and mental health measures. Univariate and multivariate analyses were conducted using RStudio (Version 0.99.903, RStudio, Inc., Boston, MA).

Results : Of the 5,106 participants with arthritis, 27 had reported a diagnosis of uveitis and 19 received ophthalmological treatment. Among those patients with self-reported uveitis, 73% were female and 37% male, and the mean age was 52.8 ± 13 years. The distribution of ethnicity was 29.6% Hispanic, 37.1% non-Hispanic white, 22.2% non-Hispanic black and 11.1% others. Positive smoking history was reported in 59.2% of the patients, the univariate analysis comparing smoking with the presence of uveitis in the arthritis population showed an OR of 1.82 (95% CI 1.11-2.96; p=0.02) and the multivariate analysis adjusting for age and gender showed an OR of 3.18 (95% CI 1.59-6.37; p=0.003). A greater age was correlated with higher uveitis prevalence (OR = 1.04, 95% CI 1.01-1.07; p=0.02). Additional analyses were performed regarding different types of arthritis (rheumatoid arthritis, osteoarthritis and psoriatic arthritis) and mental health status (anxiety and depression) and there was no correlation with uveitis.

Conclusions : Our study has found that smoking and age are positively correlated with the diagnosis of uveitis in the arthritis cohort of a population-based study and that may be risk factors for the prevalence of this disease, which can have clinical relevance since smoking is a modifiable habit.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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