June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Vitamin D and Vision
Author Affiliations & Notes
  • Dayna S Dalton
    Ophthalmology and Visual Science, University of Wisconsin, Madison, Wisconsin, United States
  • Carla Schubert
    Ophthalmology and Visual Science, University of Wisconsin, Madison, Wisconsin, United States
  • Aaron Alex Pinto
    Ophthalmology and Visual Science, University of Wisconsin, Madison, Wisconsin, United States
  • Barbara E K Klein
    Ophthalmology and Visual Science, University of Wisconsin, Madison, Wisconsin, United States
  • Ronald Klein
    Ophthalmology and Visual Science, University of Wisconsin, Madison, Wisconsin, United States
  • Adam J Paulsen
    Ophthalmology and Visual Science, University of Wisconsin, Madison, Wisconsin, United States
  • Karen J Cruickshanks
    Ophthalmology and Visual Science, University of Wisconsin, Madison, Wisconsin, United States
    Population Health Sciences, University of Wisconsin, Madison, Wisconsin, United States
  • Footnotes
    Commercial Relationships   Dayna Dalton, None; Carla Schubert, None; Aaron Pinto, None; Barbara Klein, None; Ronald Klein, None; Adam Paulsen, None; Karen Cruickshanks, None
  • Footnotes
    Support  NIH Grant AG021917 and an unrestricted grant from Research to Prevent Blindness
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 2208. doi:
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    • Get Citation

      Dayna S Dalton, Carla Schubert, Aaron Alex Pinto, Barbara E K Klein, Ronald Klein, Adam J Paulsen, Karen J Cruickshanks; Vitamin D and Vision. Invest. Ophthalmol. Vis. Sci. 2017;58(8):2208.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Vitamin D is essential for good health and low levels have been associated with a number of problems with aging. Visual function declines with age but few studies have looked at the relationship between low vitamin D and visual acuity (VA) or contrast sensitivity (CS). We investigated the association between vitamin D and VA and CS in the baseline examination of the Beaver Dam Offspring Study (BOSS; 2005-2008), a large cohort study of sensory health and aging.

Methods : While wearing trial frames containing best correction as determined by a Grand Seiko auto-refractor, VA was measured using ETDRS LogMAR charts and CS was measured with Pelli-Robson charts following standardized protocols. VA was evaluated as total number of letters correctly identified. CS was evaluated continuously (number of triplets identified) and categorically (impaired (<1.55 log triplets) vs. not impaired). Serum samples obtained at baseline and stored at -80° C were analyzed in 2015 for total vitamin D and vitamin D3. Multivariable linear and logistic regression models were used to assess the association between low vitamin D and D3, defined as the lowest quintile (Q1 <23.3 ng/ml or < 19.3 ng/mL, respectively, compared to Q5 > 39.83 ng/ml or > 36.21 ng/ml respectively) and CS and VA.

Results : There were 2392 participants aged 21-84 (average 49) years with vitamin D and vision measures. Adjusting for age and sex, participants with low total vitamin D identified significantly fewer CS triplets correctly (β -0.09 log triplets; p=0.04 Q1 vs. Q5). However, this association was no longer significant after adjusting for age, sex, education, smoking, diabetes, hypertension, and exercise or after further adjustment for supplement use or outdoor occupation. There was no association between total vitamin D and CS impairment or VA in either age- and sex-adjusted or multivariable models or between vitamin D3 and VA and CS.

Conclusions : In this middle-aged cohort with good vision, low vitamin D levels were not associated with visual function measures.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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