June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Ocular lesions in the pediatric population: A 10-year retrospective, topographic histopathological study
Author Affiliations & Notes
  • Aaron I Rosen
    MUHC - McGill University Ocular Pathology Laboratory, Montreal, Quebec, Canada
    Ophthalmology, McGill University, Montreal, Quebec, Canada
  • Rafael Reis Pereira
    MUHC - McGill University Ocular Pathology Laboratory, Montreal, Quebec, Canada
  • Rafael Frederico Peres
    MUHC - McGill University Ocular Pathology Laboratory, Montreal, Quebec, Canada
  • Patrick T Logan
    MUHC - McGill University Ocular Pathology Laboratory, Montreal, Quebec, Canada
  • Jacqueline Coblentz
    MUHC - McGill University Ocular Pathology Laboratory, Montreal, Quebec, Canada
  • Miguel N Burnier
    MUHC - McGill University Ocular Pathology Laboratory, Montreal, Quebec, Canada
    Ophthalmology, McGill University, Montreal, Quebec, Canada
  • Footnotes
    Commercial Relationships   Aaron Rosen, None; Rafael Pereira, None; Rafael Peres, None; Patrick Logan, None; Jacqueline Coblentz, None; Miguel Burnier, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 2422. doi:
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      Aaron I Rosen, Rafael Reis Pereira, Rafael Frederico Peres, Patrick T Logan, Jacqueline Coblentz, Miguel N Burnier; Ocular lesions in the pediatric population: A 10-year retrospective, topographic histopathological study. Invest. Ophthalmol. Vis. Sci. 2017;58(8):2422.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To the best of our knowledge, the prevalence of ocular lesions in the pediatric population according to both clinical and histopathological diagnoses has never been systematically studied in the literature. Herein, we conducted a review of all pediatric periocular and ocular lesions submitted to a single hospital centre over a 10-year period to determine the prevalence of clinical and pathological diagnoses based on topographical location.

Methods : A retrospective study was conducted on all periocular and ocular pathological specimens of patients aged 0 to 16 years. All specimens sent to the Henry C. Witelson Ocular Pathology Laboratory and Registry between 2006 and 2016 were included, which comprised specimens from the Montreal Children’s Hospital as well as consultation cases from several external centres. Lesions were classified according to demographic data, biopsy site, clinical diagnosis, histopathological diagnosis, and topographical location. Topographical locations were as follows: periocular (eyebrow and skin around the eye), palpebral (upper/lower eyelids & medial/lateral canthi), conjunctival, corneal, intraorbital (within orbit but external to the globe), and intraocular (within the globe).

Results : A total of 7471 patients were identified from the initial search. Limiting our dataset to include only ocular and periocular lesions yielded a total of 676 patients and 837 specimens. Mean age of all patients was 7.0 years, with no sex predilection (331 male/344 female). Lesions were distributed as follows: 323 intraorbital (38.7%), 256 palpebral (30.7%), 165 periocular (20.5%), 51 conjunctival (6.1%), 34 intraocular (4.1%), and 5 corneal (0.6%). The most frequently excised lesions overall were striated muscle (310; 37.2%), dermoid cysts (129; 15.5%), chalazia (85; 10.2%), molluscum contagiosum (32; 3.8%), and pilomatrixoma (27; 3.2%).

Conclusions : Striated muscle obtained from strabismus surgery, dermoid cysts and chalazia were the most common histopathologically diagnosed lesions over the 10-year study period in the pediatric population. Several rare lesions were found to have higher prevalence rates than have been reported in the literature. Prevalence rates gathered from this study can be used by clinicians to better establish accurate differential diagnoses when confronted with ocular and periocular lesions.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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