June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Retinal Ganglion Cells Layer thickness as a possible bio-marker for accelerate ageing due to Human Immunodeficiency Virus infection
Author Affiliations & Notes
  • Alessandro Invernizzi
    Department of Biomedical and Clinical Science "Luigi Sacco", University of Milan, Milan, Italy
    Save Sight Institute - University of Sydney, Sydney, New South Wales, Australia
  • Alessandra Acquistapace
    Department of Biomedical and Clinical Science "Luigi Sacco", University of Milan, Milan, Italy
  • Sara Bochicchio
    Department of Biomedical and Clinical Science "Luigi Sacco", University of Milan, Milan, Italy
  • Chiara Resnati
    Department of Clinical Sciences, Luigi Sacco Hospital, Section of Infectious and Tropical Diseases, University of Milan, Milan, Italy
  • Simone Pomati
    Center for Research and Treatment on Cognitive Dysfunctions, Institute of Clinical Neurology, Department of Clinical Sciences, Luigi Sacco Hospital, University of Milan, Milan, Italy
  • Alexander Klistorner
    Save Sight Institute - University of Sydney, Sydney, New South Wales, Australia
  • Giovanni Staurenghi
    Department of Biomedical and Clinical Science "Luigi Sacco", University of Milan, Milan, Italy
  • Agostino Riva
    Department of Clinical Sciences, Luigi Sacco Hospital, Section of Infectious and Tropical Diseases, University of Milan, Milan, Italy
  • Footnotes
    Commercial Relationships   Alessandro Invernizzi, Allergan (R); Alessandra Acquistapace, None; Sara Bochicchio, None; Chiara Resnati, None; Simone Pomati, None; Alexander Klistorner, None; Giovanni Staurenghi, Alcon (C), Allergan (C), Bayer (C), Canon (C), GlaxoSmithKline (C), Heidelberg Engineering (C), Ocular Instruments (P), OD-OS (C), Optos (C), Optovue (S), Pfizer (C), QLT Phototherapeutics (C), Zeiss (S); Agostino Riva, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 2589. doi:
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      Alessandro Invernizzi, Alessandra Acquistapace, Sara Bochicchio, Chiara Resnati, Simone Pomati, Alexander Klistorner, Giovanni Staurenghi, Agostino Riva; Retinal Ganglion Cells Layer thickness as a possible bio-marker for accelerate ageing due to Human Immunodeficiency Virus infection. Invest. Ophthalmol. Vis. Sci. 2017;58(8):2589.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To measure the thickness of different retinal layers by spectral domain optical coherence tomography (SD-OCT) in patients affected by Human Immunodeficiency Virus (HIV) with well controlled disease, and to correlate it with subject age, sex, disease duration, CD4 nadir, use of thymidine analogues, and cognitive status.

Methods : HIV subjects with well controlled disease between 40 and 70 years, and sex- age-matched controls were enrolled. On one eye from each subject Ganglion cells layer (GCL), Inner Plexyform Layer (IPL) and Outer Nuclear Layer (ONL) thickness was assessed on a 30x25 degrees SD-OCT volume centered onto the fovea by an automatic segmentation algorithm (Eye Explorer 1.9.10.0, Heidelberg). Mean thickness was calculated for each layer. Retinal Nerve Fiber Layer (RNFL) thickness was automatically calculated on a circumpapillary scan. Layers’ thickness was compared between HIV patients and controls. The effect of age and sex on the thickness of all the studied layers was tested through a multivariate regression analysis in both groups. In HIV patients the same analysis also considered disease duration, CD4+ nadir, use of thymidine analogues, and cognitive status of the patient (assessed through Montreal Cognitive Assessment (MoCA)Test).

Results : Sixtynine HIV patients (21 females; age 53±7,3 years) and 65 age- and sex- matched controls were enrolled. No significant difference in the thickness of any of the studied layers was found between the two groups. In HIV subjects thickness of GCL and IPL significantly decreased with age (p=0.001 and p=0.02 respectively). This was not seen in controls. ONL and RNFL didn’t show changes with ageing. Gender didn’t affect any of the layers’ thickness in both groups. MoCA Test score significantly decreased with ageing much more in HIV subjects (p=0.0009) than in controls (p=0.047). In the HIV group a positive correlation was found between GCL thickness and MoCA Test score (p=0.04). In HIV patients, layers’ thickness was not influenced by disease duration, CD4+ nadir and use of thymidine analogues.

Conclusions : GCL and IPL thickness is strongly correlated with age in HIV subjects. This doesn’t happen in controls. GCL thickness and cognitive function are correlated in HIV subjects. GCL thickness could be a possible biomarker for central nervous system accelerate ageing induced by chronic HIV infection.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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