June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Platelet-rich Plasma Eye Drops in the Healing of Post-Keratoplasty Persistent Corneal Epithelial Defects
Author Affiliations & Notes
  • Sahar Balagholi
    Ocular Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran (the Islamic Republic of)
    Department of Hematology, School of Allied Medicine, Tehran University of Medical Sciences, Tehran, Iran (the Islamic Republic of)
  • Mozhgan Rezaeikanavi
    Ocular Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran (the Islamic Republic of)
  • Shaban Alizadeh
    Department of Hematology, School of Allied Medicine, Tehran University of Medical Sciences, Tehran, Iran (the Islamic Republic of)
  • Alireza Baradaran-Rafiei
    Ocular Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran (the Islamic Republic of)
  • Siamak Delfazaye Baher
    Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran (the Islamic Republic of)
  • Behnam Ranjbar
    Department of Hematology, School of Allied Medicine, Tehran University of Medical Sciences, Tehran, Iran (the Islamic Republic of)
  • Footnotes
    Commercial Relationships   Sahar Balagholi, None; Mozhgan Rezaeikanavi, None; Shaban Alizadeh, None; Alireza Baradaran-Rafiei, None; Siamak Delfazaye Baher, None; Behnam Ranjbar, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 2639. doi:
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      Sahar Balagholi, Mozhgan Rezaeikanavi, Shaban Alizadeh, Alireza Baradaran-Rafiei, Siamak Delfazaye Baher, Behnam Ranjbar; Platelet-rich Plasma Eye Drops in the Healing of Post-Keratoplasty Persistent Corneal Epithelial Defects. Invest. Ophthalmol. Vis. Sci. 2017;58(8):2639.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate the effect of platelet-rich plasma (PRP) eye drops in the healing of post-keratoplasty persistent corneal epithelial defects.

Methods : Forty patients with persistent corneal epithelial defects following keratoplasty were treated with PRP eye drops four times a day. PRP eye drops were prepared with a low and high speed centrifuge method and final platelet counts were between 600000-800000 plt/µl for different ages and gender. Mean duration of treatment to complete epithelial healing was compared with mean duration of conventionally-treated corneal defects before the PRP treatment by paired t-test. Mean duration of treatment was also statistically analyzed between ages and gender by ANOVA test.

Results : PRP eye drops led to rapid healing of persistent corneal epithelial defects in all patients. Mean duration of treatment to complete epithelial healing was 2.49 ± 1.23 weeks and significantly less than the mean duration of conventionally-treated corneal defects before PRP treatment (6.82± 1.25wk) (P < 0.001). Mean duration of treatment was not statistically significant between different ages and gender (2.6 week in Female versus 2.3 weeks in Male).

Conclusions : Treatment with autologous PRP eye drops is an effective and reliable approach that accelerates healing of post-transplantation persistent corneal epithelial defects.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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