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josefina Andrea mejias smith, Luis Oswaldo Izquierdo Villavicencio, Maria Alejandra Henriquez Bertaggia, Carmen Olga Maldonado Matos, Nadia Canorio Pariona, Ana Luisa Gonzalez Mendez; Clinical and cytological results of Dry Eye in patients with Rosacea using adjuvant treatment with Omega 3 Fatty Acids.. Invest. Ophthalmol. Vis. Sci. 2017;58(8):2707.
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© ARVO (1962-2015); The Authors (2016-present)
Dry eye disease is a common, but complex multifactorial progressive disease that can lead to visual loss, ocular surface damage, discomfort and overall reduction in quality of life. The cytology of the ocular surface in patients with evaporative dry eye is altered in most cases, characterized by a decrease in goblet cells. In ocular rosacea, the meibomian gland dysfunction has been reported in the most patients. Recent studies had shown good results using dietary supplementation with omega-3 fatty acids in the treatment and prevention of dry eye disease. The main purpose is to describe the clinical and cytological results of the use of Omega 3 in patients with Dry eye secondary to Rosacea disease.
A prospective follow-up cases series, between November 2016 and May 2017, we will enroll 40 eyes for 20 patients. Tear rupture time (TBUT), ocular surface cytology, OSDI questionnarie, Morisky Green test, presence of Demodex Foliculorum and thorough clinical evaluation at the first visit and in controls at 1 month, 2 months, 3 months and 6 months, will done.
The study is being carried out, fourteen eyes from 7 patients, 28,57%(2) female, 71,4(5) male has been enrolled until now. The mean age was 31,2(+/-11,5) about the clinical severity was 28,5%(2)mild, 71,43%(5) moderate. The whole patients were evaluated for a Dermatologist, who confirmed the Rosacea disease. All eyes showed the presence of Demodex Foliculorum at the first evaluation. The lacrimal meniscus shows at baseline a mean of 0,29(+/- 0,071) in the temporal región, 0,266 (+/- 0,069) in the mild región and 0,26(+/- 0,051) in the nasal región. The TBUT in the first measure was 7,58(+/- 4,16) and the mean measure was 10,62(+/- 5,67) at baseline. The cytology was altered in the first control in the whole of the patients, the eyes with moderate classification shows a relation nucleus/cytoplasm 1/3, a lower amount of globet cells (21,3 +/- 4,6) and larger intercellular spaces with basophil cytoplasm at the baseline. We will update the outcomes with the whole sample at the end of the follow-up.
We will try to prove that adjuvant treatment with Omega 3 fatty acids, in patients with dry eye disease with diagnosis of Ocular Rosacea, generates a symptom and objective clinical improvement, reducing the severity of disease and improving the characteristics of ocular cytology.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
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