June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Associations between epiretinal membrane hiistology findings with clinical and optical coherence tomography findings
Author Affiliations & Notes
  • Ajay E. Kuriyan
    Flaum Eye Institute, University of Rochester Medical Center, Rochester, New York, United States
    Bascom Palmer Eye Institute, Univ of Miami/Miller School of Medicine, Miami, Florida, United States
  • Antonio Bermudez
    Bascom Palmer Eye Institute, Univ of Miami/Miller School of Medicine, Miami, Florida, United States
  • Nidhi Relhan
    Bascom Palmer Eye Institute, Univ of Miami/Miller School of Medicine, Miami, Florida, United States
  • Maria Paula Fernandez
    Bascom Palmer Eye Institute, Univ of Miami/Miller School of Medicine, Miami, Florida, United States
  • William Smiddy
    Flaum Eye Institute, University of Rochester Medical Center, Rochester, New York, United States
  • Harry W Flynn
    Bascom Palmer Eye Institute, Univ of Miami/Miller School of Medicine, Miami, Florida, United States
  • Sander R Dubovy
    Bascom Palmer Eye Institute, Univ of Miami/Miller School of Medicine, Miami, Florida, United States
  • Footnotes
    Commercial Relationships   Ajay Kuriyan, None; Antonio Bermudez, None; Nidhi Relhan, None; Maria Paula Fernandez, None; William Smiddy, None; Harry Flynn, None; Sander Dubovy, None
  • Footnotes
    Support  This research is funded in part by NIH R01 EY008684-10S1 (Bethesda, Maryland), Stanley J. Glaser Foundation Biomedical Research Support Grant (Miami, Florida), NIH Center Core Grant P30EY014801 (Bethesda, Maryland), Research to Prevent Blindness Unrestricted Grant (New York, New York), and the Department of Defense (DOD Grant #W81XWH-09-1-0675) (Washington, DC).
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 2821. doi:
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      Ajay E. Kuriyan, Antonio Bermudez, Nidhi Relhan, Maria Paula Fernandez, William Smiddy, Harry W Flynn, Sander R Dubovy; Associations between epiretinal membrane hiistology findings with clinical and optical coherence tomography findings. Invest. Ophthalmol. Vis. Sci. 2017;58(8):2821.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Epiretinal membranes (ERMs) are a common macular pathology. We studied the associations between ERM pathology specimens and clinical and optical coherence tomography (OCT) features.

Methods : Clinical records and OCT images of ERM surgery patients were reviewed. ERM specimens were graded on cellularity, fibrosis, pigment, and immunostaining for alpha-smooth muscle actin (SMA), glial fibrillary acidic protein (GFAP), and keratin.

Results : Twenty-two idiopathic and 17 secondary (11 post-RD and 6 PDR) patients were identified. Idiopathic ERMs without lamellar holes had higher cellularity (P = .025), higher alpha-smooth muscle actin staining (P = .041), and less fibrosis (P = .025), compared to other specimens. Post-RD ERMs had more pigment than other specimens (P = .010). High GFAP staining was associated with thicker OCTs (P < .001).

Conclusions : There are differences in cellular makeup of ERMs depending on the clinical presentation and OCT features. High ERM GFAP staining is associated with thicker OCTs.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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