June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Protective effect of biodegradable collagen implant in thinned sclera after strabismus surgery : paired eye study
Author Affiliations & Notes
  • Tae Keun Yoo
    Ophthalmology, Yonsei University College of Medicine, Seoul, Yonsei-ro, Seodaemun-gu, Seoul , Korea (the Republic of)
  • seung-han han
    Ophthalmology, Yonsei University College of Medicine, Seoul, Yonsei-ro, Seodaemun-gu, Seoul , Korea (the Republic of)
  • Jinu Han
    Ophthalmology, Yonsei University College of Medicine, Seoul, Yonsei-ro, Seodaemun-gu, Seoul , Korea (the Republic of)
  • Footnotes
    Commercial Relationships   Tae Keun Yoo, None; seung-han han, None; Jinu Han, None
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 2925. doi:
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    • Get Citation

      Tae Keun Yoo, seung-han han, Jinu Han; Protective effect of biodegradable collagen implant in thinned sclera after strabismus surgery : paired eye study. Invest. Ophthalmol. Vis. Sci. 2017;58(8):2925.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To determine protective effect of a biodegenerable Ologen™ collagen matrix (OCM) in reducing blue-color change due to exposed thinned sclera after strabismus surgery.

Methods : This prospective, randomized, paired-eye control study included 14 patients with intermittent exotropia. All procedures were performed at the Severance hospital, Seoul, South Korea. All patients underwent symmetrical bilateral lateral rectus recession. The OCM was implanted at original rectus insertion site in randomly selected one-eye and the other eye underwent conventional surgery. The OCM was implanted under conjunctiva without suture, covering the muscle insertion site. Primary outcome was color changes of conjunctiva measured using computer-based image analysis developed for grading conjunctiva at immediate, 1 week, 1 months, 3 months after surgery. Slit-lamp photograph of each eye was evaluated using contrast limited adaptive histogram equalization (CLAHE), Canny edge, and RGB model. Secondary outcome was thickness of conjunctiva and sclera at 3 months after surgery using an anterior segmental optical coherence tomography.

Results : The mean age at the time of surgery was 20.9±8.9 years. The mean amount of lateral rectus recession was 8.18±1.35 mm. No intraoperative complications were observed. At immediate postoperative and 1 week after surgery, all color models were no significant difference between the OCM-implanted eyes and the control eyes. At 3 months after surgery, the OCM-implanted eyes showed significantly lower values of CLAHE and blue color of RGB model than the control eyes (P=0.041 and P=0.008). There was no statistically significant difference in Canny edge and red color of RGB model (P=0.061 and P=0.152). The thickness of conjunctival stroma and episclera in the OCM-implanted eyes was significantly increased than that in the control eyes (P=0.001). There was no significant association in the thickness of conjunctival epithelium and sclera stroma between the OCM-implanted and control eyes (P=0.773 and P=0.209).

Conclusions : After strabismus surgery, the blue-color change was reduced significantly in the OCM-implanted eyes than the control eyes. Our study suggests that implantation of OCM can protect bluing sclera at original rectus insertion site after lateral rectus recession.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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