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Seung-Young Yu, Kiyoung Kim, Eung-Suk Kim; Association between retinal neurodegeneration and foveal avascular zone in diabetic eyes: OCTA analysis. Invest. Ophthalmol. Vis. Sci. 2017;58(8):2951.
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To evaluate the correlation of ganglion cell-inner plexiform (GC-IPL) thickness with area of foveal avascular zone (FAZ) using OCTA in diabetic eyes
Medical records of diabetic patients without retinopathy (n=40), diabetic patients with mild to moderate NPDR (n=60), and healthy eyes (n=40) were reviewed. The mean parafoveal GC-IPL thickness were measured using Cirrus HD-OCT (Carl Zeiss). The FAZ area in the superficial and deep plexus layers were measured and evaluated using OCT angiography (Angioplex, Carl Zeiss)
The FAZ area in the superficial and deep capillary plexus layer was 0.31±0.10mm2, 0.39±0.11mm2 in healthy eyes, whereas 0.39±0.13mm2, 0.46±0.14mm2 in diabetic eyes without retinopathy and 0.37±0.15mm2, 0.44±0.12mm2 in eyes with diabetic retinopathy. Diabetic eyes showed statistically significant FAZ enlargement in both superficial and deep layer compared with healthy eyes. The FAZ area and GC-IPL thickness were significantly correlated in both diabetic groups (p=0.03, p<0.001), whereas it was not significant in control (p=0.894)
Both enlargement of FAZ and retinal neurodegneration occurs in early diabetic retinopathy regardless of presence of retinopathy. Also, FAZ area and GC-IPL thickness were numerically correlated in diabetic eyes
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
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