June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Association between retinal neurodegeneration and foveal avascular zone in diabetic eyes: OCTA analysis
Author Affiliations & Notes
  • Seung-Young Yu
    Ophthalmology, Kyung Hee University, Seoul, Korea (the Republic of)
  • Kiyoung Kim
    Ophthalmology, Kyung Hee University, Seoul, Korea (the Republic of)
  • Eung-Suk Kim
    Ophthalmology, Kyung Hee University, Seoul, Korea (the Republic of)
  • Footnotes
    Commercial Relationships   Seung-Young Yu, None; Kiyoung Kim, None; Eung-Suk Kim, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 2951. doi:
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      Seung-Young Yu, Kiyoung Kim, Eung-Suk Kim; Association between retinal neurodegeneration and foveal avascular zone in diabetic eyes: OCTA analysis. Invest. Ophthalmol. Vis. Sci. 2017;58(8):2951.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate the correlation of ganglion cell-inner plexiform (GC-IPL) thickness with area of foveal avascular zone (FAZ) using OCTA in diabetic eyes

Methods : Medical records of diabetic patients without retinopathy (n=40), diabetic patients with mild to moderate NPDR (n=60), and healthy eyes (n=40) were reviewed. The mean parafoveal GC-IPL thickness were measured using Cirrus HD-OCT (Carl Zeiss). The FAZ area in the superficial and deep plexus layers were measured and evaluated using OCT angiography (Angioplex, Carl Zeiss)

Results : The FAZ area in the superficial and deep capillary plexus layer was 0.31±0.10mm2, 0.39±0.11mm2 in healthy eyes, whereas 0.39±0.13mm2, 0.46±0.14mm2 in diabetic eyes without retinopathy and 0.37±0.15mm2, 0.44±0.12mm2 in eyes with diabetic retinopathy. Diabetic eyes showed statistically significant FAZ enlargement in both superficial and deep layer compared with healthy eyes. The FAZ area and GC-IPL thickness were significantly correlated in both diabetic groups (p=0.03, p<0.001), whereas it was not significant in control (p=0.894)

Conclusions : Both enlargement of FAZ and retinal neurodegneration occurs in early diabetic retinopathy regardless of presence of retinopathy. Also, FAZ area and GC-IPL thickness were numerically correlated in diabetic eyes

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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