June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Ripasudil (K-115) elicits dilation of isolated porcine retinal arterioles
Author Affiliations & Notes
  • Takayuki Kamiya
    Asahikawa Medical University, Asahikawa, Japan
  • Taiji Nagaoka
    Asahikawa Medical University, Asahikawa, Japan
  • Motofumi Kawai
    Asahikawa Medical University, Asahikawa, Japan
  • Tsuneaki Omae
    Asahikawa Medical University, Asahikawa, Japan
  • Seigo Nakabayashi
    Asahikawa Medical University, Asahikawa, Japan
  • Shinji Ono
    Asahikawa Medical University, Asahikawa, Japan
  • Kengo Takahashi
    Asahikawa Medical University, Asahikawa, Japan
  • Akira Tanner
    Asahikawa Medical University, Asahikawa, Japan
  • Akitoshi Yoshida
    Asahikawa Medical University, Asahikawa, Japan
  • Footnotes
    Commercial Relationships   Takayuki Kamiya, Kowa (F); Taiji Nagaoka, None; Motofumi Kawai, None; Tsuneaki Omae, None; Seigo Nakabayashi, None; Shinji Ono, None; Kengo Takahashi, None; Akira Tanner, None; Akitoshi Yoshida, Nidek (P), TOMEY (P), Topcon (P)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 3032. doi:
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    • Get Citation

      Takayuki Kamiya, Taiji Nagaoka, Motofumi Kawai, Tsuneaki Omae, Seigo Nakabayashi, Shinji Ono, Kengo Takahashi, Akira Tanner, Akitoshi Yoshida; Ripasudil (K-115) elicits dilation of isolated porcine retinal arterioles
      . Invest. Ophthalmol. Vis. Sci. 2017;58(8):3032.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Ripasudil (K-115), a Rho kinase inhibitor, has an intraocular pressure-lowering effect. In our previous study, we found that administration of intravitreal ripasudil increased the retinal blood flow in cats. However, the mechanism underlying the effect of ripasudil on the retinal microcirculation is unknown. Therefore, we investigated the direct effect of ripasudil on the retinal arterioles in pigs and the mechanism underlying the ripasudil-mediated effect.

Methods : The porcine retinal arterioles were isolated, cannulated, and pressurized at 55 cm H2O without flow for the in vitro study. Diameter changes were recorded using videomicroscopic techniques.

Results : Ripasudil elicited dilation of the isolated retinal arterioles in a dose-dependent (100 pM-30 µM) manner within 3 minutes. Pretreatment with NG-nitro-L- arginine methyl ester and denudation did not inhibit the effect of ripasudil on the retinal arterioles.

Conclusions : Ripasudil elicits endothelium-independent vasodilation of the retinal arterioles.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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