June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Retinal Blood Flow in Glaucomatous Eyes with Single Hemifield Damage
Author Affiliations & Notes
  • takafumi yoshioka
    Asahikawa Medical University, Asahikawa Medical University, Asahikawa, Japan
  • Takayuki Kamiya
    Asahikawa Medical University, Asahikawa Medical University, Asahikawa, Japan
  • Motofumi Kawai
    Asahikawa Medical University, Asahikawa Medical University, Asahikawa, Japan
  • Tomofumi Tani
    Asahikawa Medical University, Asahikawa Medical University, Asahikawa, Japan
  • Seigo Nakabayashi
    Asahikawa Medical University, Asahikawa Medical University, Asahikawa, Japan
  • Masahiro Akiba
    Topcon Corp, Tokyo, Japan
  • Akitoshi Yoshida
    Asahikawa Medical University, Asahikawa Medical University, Asahikawa, Japan
  • Footnotes
    Commercial Relationships   takafumi yoshioka, None; Takayuki Kamiya, None; Motofumi Kawai, None; Tomofumi Tani, None; Seigo Nakabayashi, None; Masahiro Akiba, Topcon Corp (E); Akitoshi Yoshida, Topcon Corp (P)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 3041. doi:
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      takafumi yoshioka, Takayuki Kamiya, Motofumi Kawai, Tomofumi Tani, Seigo Nakabayashi, Masahiro Akiba, Akitoshi Yoshida; Retinal Blood Flow in Glaucomatous Eyes with Single Hemifield Damage. Invest. Ophthalmol. Vis. Sci. 2017;58(8):3041.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To examine the hypotheses that in glaucomatous eyes with single hemifield damage, retinal blood flow (RBF) is significantly reduced in retinal hemisphere corresponding abnormal visual hemifield; and that there are significant associations between MD value in abnormal hemifield, RBF, and structural measurements in the corresponding hemisphere.

Methods : Six eyes of 19 glaucoma patients with visual field loss confined to a single hemifield.Glaucomatous eyes underwent Doppler Optical Coherence Tomography Auto-Flowmeter (auto-DOCT) and standard automated perimetry. Auto-DOCT with a segmental scanning was used to measure RBF. RBF was derived from the recorded doppler frequency shift and the measured angle between the beam and the vessel. RBF in temporal artery and retinal nerve fiber layer (RNFL) values were calculated. Statistical analyses were performed.

Results : The RBF was reduced in abnormal hemisphere compared to the opposite hemisphere (6.86±2.33 vs 3.99±2.03μL/min, p<0.0001). The RNFL was thinner in the corresponding abnormal hemisphere compared with the opposite hemisphere (78.1±21.1, 104.3±15.5μm, p=0.0001). The RBF was correlated with RNFL (r=0.500, p=0.029) in the normal hemisphere, but was not correlated with RNFL (r=0.072, p=0.761) and MD value (r=0.215, p=0.3779) in the abnormal hemisphere.

Conclusions : In glaucomatous eyes with single-hemifield damage, the RBF is significantly reduced in the hemisphere associated with the abnormal hemifield. Reduced RBF is associated with thinner RNFL in the corresponding abnormal hemisphere.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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