June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
The correlation between corneal biomechanics and corneal morphology in the early stage of overnight orthokeratology
Author Affiliations & Notes
  • Renai Chen
    Optometry Department, The Affiliated Eye Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
  • Hua Bi
    College of Optometry, NOVA Southeastern University, Davie, Florida, United States
  • Xinjie Mao
    Optometry Department, The Affiliated Eye Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
  • Meixiao Shen
    Optometry Department, The Affiliated Eye Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
  • Jun Jiang
    Optometry Department, The Affiliated Eye Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
  • Fan Lu
    Optometry Department, The Affiliated Eye Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
  • Footnotes
    Commercial Relationships   Renai Chen, None; Hua Bi, None; Xinjie Mao, None; Meixiao Shen, None; Jun Jiang, None; Fan Lu, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 3048. doi:
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    • Get Citation

      Renai Chen, Hua Bi, Xinjie Mao, Meixiao Shen, Jun Jiang, Fan Lu; The correlation between corneal biomechanics and corneal morphology in the early stage of overnight orthokeratology. Invest. Ophthalmol. Vis. Sci. 2017;58(8):3048.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Overnight orthokeratology causes changes in corneal morphology, such as corneal curvature, corneal thickness. It was also reported overnight orthokeratology reduced corneal biomechanics including corneal hysteresis (CH) and corneal resistance factor (CRF). In this study, we tried to find the relationships between the changes of corneal biomechanics and corneal morphology in the early stage of overnight orthokeratology.

Methods : Twenty-seven subjects wearing orthokeratology lens were recruited from the Eye Clinic at Wenzhou Medical University. Baseline data were collected at day 0. Twenty-five of the subjects finished the first day follow-up and 23 of them completed the 7-day follow-up. CH and CRF were measured with an ocular response analyzer, corneal curvature was measured with Medmont E300 corneal topographer, and other morphological changes were measured with a custom-built ultra-high resolution coherence tomography(UHR-OCT) with 3um axial resolution and approximately 2mm imaging depth. One-way ANOVA with repeated measure was used to compare the longitudinal changes and partial least squares linear regression (PLSLR) was used to explore the relationships between corneal biomechanics and corneal morphology.

Results : At baseline, both CH and CRF were positively correlated with central corneal thickness (CCT) (p=0.02, p<0.01 respectively), central stroma thickness (CST) (p=0.02, p=0.01 respectively), rather than central epithelial thickness (CET) (p=0.88, p=0.62 respectively)and central Bowman’s layer thickness (CBT) (p=0.49, p=0.17 respectively). At day 1 and day 7 follow-up, neither the change of CH (ΔCH) nor the change of CRF (ΔCRF) was correlated with any changes of corneal curvature and corneal thickness.

Conclusions : While corneal mechanics (CH and CRF) were positively correlated with CCT and CST at baseline, the changes of CH and CRF were not correlated with any changes in corneal morphology in the early stage of overnight orthokeratology.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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