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Renai Chen, Hua Bi, Xinjie Mao, Meixiao Shen, Jun Jiang, Fan Lu; The correlation between corneal biomechanics and corneal morphology in the early stage of overnight orthokeratology. Invest. Ophthalmol. Vis. Sci. 2017;58(8):3048.
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© ARVO (1962-2015); The Authors (2016-present)
Overnight orthokeratology causes changes in corneal morphology, such as corneal curvature, corneal thickness. It was also reported overnight orthokeratology reduced corneal biomechanics including corneal hysteresis (CH) and corneal resistance factor (CRF). In this study, we tried to find the relationships between the changes of corneal biomechanics and corneal morphology in the early stage of overnight orthokeratology.
Twenty-seven subjects wearing orthokeratology lens were recruited from the Eye Clinic at Wenzhou Medical University. Baseline data were collected at day 0. Twenty-five of the subjects finished the first day follow-up and 23 of them completed the 7-day follow-up. CH and CRF were measured with an ocular response analyzer, corneal curvature was measured with Medmont E300 corneal topographer, and other morphological changes were measured with a custom-built ultra-high resolution coherence tomography(UHR-OCT) with 3um axial resolution and approximately 2mm imaging depth. One-way ANOVA with repeated measure was used to compare the longitudinal changes and partial least squares linear regression (PLSLR) was used to explore the relationships between corneal biomechanics and corneal morphology.
At baseline, both CH and CRF were positively correlated with central corneal thickness (CCT) (p=0.02, p<0.01 respectively), central stroma thickness (CST) (p=0.02, p=0.01 respectively), rather than central epithelial thickness (CET) (p=0.88, p=0.62 respectively)and central Bowman’s layer thickness (CBT) (p=0.49, p=0.17 respectively). At day 1 and day 7 follow-up, neither the change of CH (ΔCH) nor the change of CRF (ΔCRF) was correlated with any changes of corneal curvature and corneal thickness.
While corneal mechanics (CH and CRF) were positively correlated with CCT and CST at baseline, the changes of CH and CRF were not correlated with any changes in corneal morphology in the early stage of overnight orthokeratology.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
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