June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Factors influencing circumpapillary retinal nerve fibre layer thickness (cRNFLT) in Northern Ireland Cohort Longitudinal Study of Ageing (NICOLA) study
Author Affiliations & Notes
  • Paul McCann
    Queens University Belfast, Belfast, Northern Ireland, United Kingdom
  • Ruth E Hogg
    Queens University Belfast, Belfast, Northern Ireland, United Kingdom
  • Augusto Azuara-Blanco
    Queens University Belfast, Belfast, Northern Ireland, United Kingdom
  • Ian Young
    Queens University Belfast, Belfast, Northern Ireland, United Kingdom
  • Frank Kee
    Queens University Belfast, Belfast, Northern Ireland, United Kingdom
  • Footnotes
    Commercial Relationships   Paul McCann, None; Ruth Hogg, None; Augusto Azuara-Blanco, None; Ian Young, None; Frank Kee, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 3136. doi:
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      Paul McCann, Ruth E Hogg, Augusto Azuara-Blanco, Ian Young, Frank Kee; Factors influencing circumpapillary retinal nerve fibre layer thickness (cRNFLT) in Northern Ireland Cohort Longitudinal Study of Ageing (NICOLA) study. Invest. Ophthalmol. Vis. Sci. 2017;58(8):3136.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : cRNFLT is influenced by ocular diseases such as glaucoma. Demographic and ocular factors including myopia may also influence cRNFLT. The influence of ocular biomechanical properties on cRNFLT has not been reported previously in an adult population based study. We report the association between demographic and ocular biomechanical factors and cRNFLT.

Methods : Cross sectional study: The NICOLA study is an ongoing population-based epidemiological study. The ophthalmic assessment includes: SD-OCT cRNFLT scans, colour stereo pairs of the optic disc and Goldmann-correlated intraocular pressure (IOPg), corneal-compensated intraocular pressure (IOPcc), corneal resistance factor (CRF) and corneal hysteresis (CH) measured using Ocular Response Analyser. Vertical cup-disc ratios (VCDRs) for the first 3001 participants were measured by trained graders who were masked to the cRNFLT measurements. Generalised Estimation Equation (GEE) models were used to enable data from both eyes to be included and multivariable confounder adjusted analysis was performed with the influence of age, sex, IOPg, CH and VCDR explored.

Results : Eyes (n=4375) and participants (n=2486) were included in GEE which demonstrated age (β, -0.139, p<0.001), female gender (β, 2.007, p<0.001), IOPg (β, -0.348, p<0.001) VCDR (per 0.1 increase) (β, -1.0817, p<0.001) and CH (β, 0.366, p=0.022) were significantly associated with cRNFLT. CRF was not associated with cRNFLT in univariate analysis (r=0.003, p=0.819) but CH was positively correlated with global cRNFLT in the multivariate analysis.

Conclusions : In addition to age, gender, IOP and VCDR we have identified that lower corneal hysteresis is associated with lower cRNFLT when adjusted for other factors.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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