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Akira Sayo, Shinji Ueno, Ayami Nakanishi, Taro Kominami, Masashi Okado, Hiroko Terasaki; Course of visual field changes in retinitis pigmentosa patients followed by Humphrey Field Analyzer 10-2 program. Invest. Ophthalmol. Vis. Sci. 2017;58(8):3218.
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© ARVO (1962-2015); The Authors (2016-present)
Retinitis pigmentosa (RP) is a hereditary retinal disease characterized by a progressive constriction of the visual field due to photoreceptor degeneration. The purpose of this study was to determine the course of visual field constriction in 31 RP patients.
We reviewed the medical records of 263 RP patients who were examined at the Nagoya University Hospital. Of these, 31 eyes of 31 patients (18 men, 13 women; mean age, 44.1±14.8) were selected because they had had at least 3 determinations of the visual fields by Humphrey Field Analyzer 10-2 program (HFA 10-2) during the follow-up period. Eyes whose baseline mean deviation (MD) was less than -30.0 dB or more than -5.0 dB were excluded, and eyes with other ocular disorders were excluded. Eyes with fixation loss of more than 20% or false-positive or false-negative errors more than 33% were also excluded. The eye with the better MD at the baseline of each patient was chosen for the statistical analyses. Of the 31 patients, 7 had autosomal dominant RP, 8 had autosomal recessive RP, 1 had X-linked RP, and 15 were diagnosed as simplex RP. A linear mixed model was used to follow the changes in the MD measurements. We determined whether the age, sex, and mode of inheritance affected the rate of progression of the MD.
The average follow-up time was 4.3±2.3 years, and the average frequency of the visual field tests was 4.84±3.47. The mean progression rate of the MD was -0.460 dB/year (SEM=0.115, P=0.0005). The age and sex did not affect the progression rate. The progression of visual field loss was not affected by the pattern of inheritance.
HFA 10-2 demonstrated the progressive nature of RP, and the mean MD progression rate was calculated with the use of mixed linear regression. Our findings and methods can be useful in counseling RP patients.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
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