June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Optical Coherence Tomography Angiography Assessment of Retinal Degeneration in Patients with Retinitis Pigmentosa.
Author Affiliations & Notes
  • Ramiro Maldonado
    Ophthalmic Genetics, National Eye Institute, Bethesda, Maryland, United States
  • Wadih M Zein
    Ophthalmic Genetics, National Eye Institute, Bethesda, Maryland, United States
  • Robert B Hufnagel
    Ophthalmic Genetics, National Eye Institute, Bethesda, Maryland, United States
  • Brian P Brooks
    Ophthalmic Genetics, National Eye Institute, Bethesda, Maryland, United States
  • Laryssa Huryn
    Ophthalmic Genetics, National Eye Institute, Bethesda, Maryland, United States
  • Footnotes
    Commercial Relationships   Ramiro Maldonado, None; Wadih Zein, None; Robert Hufnagel, None; Brian Brooks, None; Laryssa Huryn, None
  • Footnotes
    Support  NIH Intramural Research Support
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 3220. doi:
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    • Get Citation

      Ramiro Maldonado, Wadih M Zein, Robert B Hufnagel, Brian P Brooks, Laryssa Huryn; Optical Coherence Tomography Angiography Assessment of Retinal Degeneration in Patients with Retinitis Pigmentosa.
      . Invest. Ophthalmol. Vis. Sci. 2017;58(8):3220.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Optical Coherence Tomography Angiography (OCTA) is a new imaging tool that provides structural information of retinal vasculature. The current study aims to evaluate vascular, photoreceptor and retinal pigment epithelium (RPE) characteristics in the macula of patients with retinitis pigmentosa utilizing OCTA.

Methods : OCTA scans were obtained using a commercially available system (AngioPlex, Carl Zeiss Meditech) in twelve patients with a clinical diagnosis of retinitis pigmentosa. Scans with artifacts related to media opacity or segmentation errors that compromised study assessment were excluded. One eye from each patient was selected for analysis. Retinal vascular supply was evaluated at the following levels: superficial and deep retinal vasculature, choriocapillaris and choroid. Photoreceptor outer segment and RPE integrity were estimated using en-face color-intensity maps by segmenting the ellipsoid-zone band and RPE respectively. Subjects were divided into three disease-severity groups depending on the maximal horizontal meridian on isopter I4e as follows: group-1 (>=60 degrees, n=3); group-2 (21-60 degrees, n=4) and group-3 (<20 degrees, n=5).

Results : Twelve patients were included in the analysis; 7 were females (58%) and the median age was 26 years (range 15-83). Seven (58%) were Caucasians, two African-American, two Asian and one Hispanic. The superficial retinal vascular layer was the least frequently affected (n=5, 42%) followed by deep vasculature and RPE (n=10, 83%), choriocapillaris (n=11, 92%) and ez-band and choroid (100%). Sub-group analysis showed that superficial vasculature was abnormal in 25%, 75% and 80% of groups 1, 2 and 3 respectively and the deep vasculature was abnormal in 50%, 75% and 100% of groups 1, 2 and 3 respectively. There was no difference in the distribution of abnormalities in other layers when comparing across severity groups.

Conclusions : OCTA may be a useful imaging tool to evaluate vascular and structural retinal changes in patients with retinitis pigmentosa. This novel technology could provide more insights in the sequence of events specific to retinal degenerations.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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