June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Retinal sensitivity in Retinitis Pigmentosa patients, MP3 Study
Author Affiliations & Notes
  • Enzo Maria Vingolo
    UOC Ophthal Hosp "A. Fiorini" Terracina, Clinica Oculistica del Policlinico Umberto I di Ro, Roma, Italy
  • serena Fragiotta
    UOC Ophthal Hosp "A. Fiorini" Terracina, Clinica Oculistica del Policlinico Umberto I di Ro, Roma, Italy
  • sergio scalinci
    Department Of Ophthalmology, University of Bologna, Bologna, Italy
  • Paolo G. Limoli
    Centro Studi Ipovisione, Milan, Italy
  • vittoria de rosa
    UOC Ophthal Hosp "A. Fiorini" Terracina, Clinica Oculistica del Policlinico Umberto I di Ro, Roma, Italy
  • Footnotes
    Commercial Relationships   Enzo Maria Vingolo, None; serena Fragiotta, None; sergio scalinci, None; Paolo Limoli, None; vittoria de rosa, None
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 3233. doi:
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    • Get Citation

      Enzo Maria Vingolo, serena Fragiotta, sergio scalinci, Paolo G. Limoli, vittoria de rosa; Retinal sensitivity in Retinitis Pigmentosa patients, MP3 Study. Invest. Ophthalmol. Vis. Sci. 2017;58(8):3233.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate the relationship between retinal structure and retinal sensitivity comparing data obtained using spectral-domain optical coherence tomography (SD-OCT) and microperimetry in retinitis pigmentosa (RP) and healthy patients.

Methods : 49 patients (98 eyes) with RP were divided into 4 groups according to the OCT findings: group A, patients with no macular changes; group B, patients with cystoid macular edema (CME); group C, patients with vitreomacular traction (VMT); group D, patients with retinal thinning. As a control group, we enrolled 27 healthy subjects. All subjects underwent a complete ophthalmologic examination, including SD-OCT and microperimetry. For the statistical analysis, Pearson correlation test and linear regression analysis were used. A p value <0.05 was considered statistically significant.

Results : No significant difference in best-corrected visual acuity (BCVA), foveal thickness, or retinal sensitivity between group A and the healthy subjects (p>0.05). In group B, linear regression of logMAR versus foveal thickness and retinal sensitivity versus foveal thickness gave r values of 0.931 and 0.786, respectively. In group C, r values were 0.786 and 0.842, respectively, while in group D they were 0.816 and 0.795.

Conclusions : our data show that microperimetry is a very important diagnostic tool in investigating retinal functoon in Retinitis Pigmentosa, which has proven to be very sensitive in detecting functional abnormalities in all the patients. the first application of the new microperimeter MP3 in patients with RPFuture studies should investigate the relationships among photoreceptor cell loss, retinal sensitivity, and fixation in patients with RP.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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