June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
The relationship between the retinal structure and visual field measured with the microperimetry: MP-3, in patients with retinitis pigmentosa.
Author Affiliations & Notes
  • Yuichi Asahina
    Ophthalmology, University of Tokyo, Tokyo, Japan
  • Hiroshi Murata
    Ophthalmology, University of Tokyo, Tokyo, Japan
  • Ryo Obata
    Ophthalmology, University of Tokyo, Tokyo, Japan
  • Tatsuya Inoue
    Ophthalmology, University of Tokyo, Tokyo, Japan
  • Ryo Asaoka
    Ophthalmology, University of Tokyo, Tokyo, Japan
  • Footnotes
    Commercial Relationships   Yuichi Asahina, None; Hiroshi Murata, None; Ryo Obata, None; Tatsuya Inoue, None; Ryo Asaoka, None
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 3242. doi:
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      Yuichi Asahina, Hiroshi Murata, Ryo Obata, Tatsuya Inoue, Ryo Asaoka; The relationship between the retinal structure and visual field measured with the microperimetry: MP-3, in patients with retinitis pigmentosa.. Invest. Ophthalmol. Vis. Sci. 2017;58(8):3242.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate the structure-function relationship between the area of remaining ellipsoid zone (EZ) and visual field (VF) measured with the microperimetry: MP-3, in patients with type 2 retinitis pigmentosa (RP).

Methods : This retrospective study included 22 eyes of 11 patients with a clinical diagnosis of RP and with different diameters of hyperautofluorescent rings on fundus autofluorescence. VF measurements were carried out with these patients, using MP-3 and Humphrey Field Analyzer (HFA, Carl-Zeiss, CA). These VF measurements were carried out using the 10-2 test grid pattern for both perimetries. In addition, optical coherence tomography (OCT, Spectralis, Heidelberg, Germany) measurement was carried out. The remaining EZ was identified using the OCT image and the boundary of the area with EZ was defined as ‘EZ edge’. Then the mean retinal sensitivities inside and outside the EZ edge were calculated. Finally, difference between the mean of retinal sensitivities inside and outside the EZ edge was evaluated and the magnitude of the difference was compared between MP-3 and HFA.

Results : 11.6±5.9 test points were located within the EZ edge. The mean retinal sensitivity inside the EZ edge was 23.4±4.0 and 30.4±3.5 dB, with MP-3 and HFA, respectively, whereas the mean retinal sensitivity outside the EZ edge was 8.7±3.7 and 19.1±4.2 dB with MP-3 and HFA, respectively. The difference between the retinal sensitivity inside and outside the EZ edge was significantly larger with MP-3 than that with HFA (p <0.001, linear mixed model).

Conclusions : Our findings reflect that MP-3 shows the difference of the retinal sensitivity between inside and outside the EZ edge more clearly than HFA.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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