June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Risk factors for Posterior Subcapsular Cataract
in Retinitis Pigmentosa
Author Affiliations & Notes
  • Jun Funatsu
    Kyushu university, Fukuoka, Fukuoka, Japan
  • Kohta Fujiwara
    Kyushu university, Fukuoka, Fukuoka, Japan
  • Yasuhiro Ikeda
    Kyushu university, Fukuoka, Fukuoka, Japan
  • Yusuke Murakami
    Kyushu university, Fukuoka, Fukuoka, Japan
  • Shunji Nakatake
    Kyushu university, Fukuoka, Fukuoka, Japan
  • Takashi Tachibana
    Kyushu university, Fukuoka, Fukuoka, Japan
  • Noriko Yoshida
    Kyushu university, Fukuoka, Fukuoka, Japan
  • Shintaro Nakao
    Kyushu university, Fukuoka, Fukuoka, Japan
  • Toshio Hisatomi
    Kyushu university, Fukuoka, Fukuoka, Japan
  • Shigeo Yoshida
    Kyushu university, Fukuoka, Fukuoka, Japan
  • Tatsuro Ishibashi
    Kyushu university, Fukuoka, Fukuoka, Japan
  • Koh-hei Sonoda
    Kyushu university, Fukuoka, Fukuoka, Japan
  • Footnotes
    Commercial Relationships   Jun Funatsu, None; Kohta Fujiwara, None; Yasuhiro Ikeda, None; Yusuke Murakami, None; Shunji Nakatake, None; Takashi Tachibana, None; Noriko Yoshida, None; Shintaro Nakao, None; Toshio Hisatomi, None; Shigeo Yoshida, None; Tatsuro Ishibashi, None; Koh-hei Sonoda, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 3243. doi:
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    • Get Citation

      Jun Funatsu, Kohta Fujiwara, Yasuhiro Ikeda, Yusuke Murakami, Shunji Nakatake, Takashi Tachibana, Noriko Yoshida, Shintaro Nakao, Toshio Hisatomi, Shigeo Yoshida, Tatsuro Ishibashi, Koh-hei Sonoda; Risk factors for Posterior Subcapsular Cataract
      in Retinitis Pigmentosa
      . Invest. Ophthalmol. Vis. Sci. 2017;58(8):3243.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Posterior subcapsular cataract (PSC) is a frequent complication in patients with retinitis pigmentosa (RP). The risk factor for PSC formation in RP is largely unknown. The purpose of this study was to investigate the risk factor for PSC.

Methods : We retrospectively studied a total of 322 eyes of 174 patients who were diagnosed with typical RP. Aqueous flare values were measured consecutively in 2012 and 2013 using a laser flare cell meter. The lens including PSC was examined at the slit lamp after dilation with tropicamide 1% and phenylephrine 2.5%.

Results : The geometric mean values of aqueous flare and mean values of visual acuity were significantly higher for the RP patients with PSC compared to those without PSC (P=0.0003, P=0.0004, respectively). When the aqueous flare values were assessed continuously, each 1-log-transformed increase in flare levels was associated with an elevation of the likelihood of having PSC after multivariable adjustment (OR, 1.80; 95% CI, 1.13–2.86). In other possible risk factors, there are no significant associations with PSC.

Conclusions : Our analysis demonstrated that elevated aqueous flare is a significant risk factor for PSC formation, suggesting that inflammation may be implicated in the pathogenesis of PSC formation in RP.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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