June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Retinal sensitivity and fixation stability as surrogate markers of visual function in molecularly confirmed choroideremia patients.
Author Affiliations & Notes
  • Vaishnavi Batmanabane
    Ophthalmology and Visual Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada
  • Ajoy Vincent
    Ophthalmology and Visual Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada
  • Elise Heon
    Ophthalmology and Visual Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada
  • Footnotes
    Commercial Relationships   Vaishnavi Batmanabane, None; Ajoy Vincent, None; Elise Heon, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 3283. doi:
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      Vaishnavi Batmanabane, Ajoy Vincent, Elise Heon; Retinal sensitivity and fixation stability as surrogate markers of visual function in molecularly confirmed choroideremia patients.. Invest. Ophthalmol. Vis. Sci. 2017;58(8):3283.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To study the microperimetry features (retinal sensitivity and fixation stability) of patients with choroideremia and correlate them with vision and visual field data.

Methods : Retrospective data of twelve patients (all male) with a molecular diagnosis of choroideremia who had been examined clinically between January 2014 and October 2016 was collected. Data collected included: demographic information, genetic testing, ophthalmic exam findings, Goldmann visual field (GVF), and microperimetry (MAIA, CenterVue, Italy) values. Outcomes assessed were logMAR vision, uniocular continuous horizontal visual field with the III4e target in degrees, retinal sensitivity (dB), and fixation stability (measured as bivariate contour ellipse area).

Results : Twelve eyes of 12 patients were included in analysis (the eye with better vision or the left eye if both eyes had equal vision). Patients’ mean age at visit was 34.83 ±15.29 years with an average logMAR vision of 0.1.8±0.18 and average GVF of 51.33±53.65 degrees. With increasing age, the vision significantly decreased (r= 0.71; p=0.009), but not the GVF (r= -0.43; p=0.15). Mean retinal sensitivity was 15.05±8.93dB and correlated well with age (r=-0.73, p=0.0066) and vision (r=-0.64, p=0.022). The fixation stability (mean= 29.05±33.68 deg2) was significantly poorer in older subjects (r=0.71; p=0.022) and in those with worse vision (r=0.71; p=0.009). In addition, fixation stability was significantly lesser (p<0.0001) in patients above the age of 30 (n=10) when compared to published age matched normalcontrols.

Conclusions : Retinal sensitivity and fixation stability measured by the MAIA microperimeter, correlate well with the vision in choroideremia. These can serve as surrogate markers of functional vision assessment in this population.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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