June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Fractal Analysis of Peripapillary Vasculature In Eyes With Papilledema Using Optical Coherence Tomography Angiography
Author Affiliations & Notes
  • Soshian Sarrafpour
    Ophthalmology, New York University, New York, New York, United States
  • Edmund Tsui
    Ophthalmology, New York University, New York, New York, United States
  • David Fell
    Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, United States
    Stony Brook University School of Medicine, Stony Brook, New York, United States
  • Sherief Raouf
    Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, United States
    Stony Brook University School of Medicine, Stony Brook, New York, United States
  • Nicole K Scripsema
    Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, United States
    Icahn School of Medicine at Mount Sinai, New York, New York, United States
  • Sarwar Zahid
    Ophthalmology, New York University, New York, New York, United States
  • Sarita B Dave
    Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, United States
  • Patricia M. Garcia
    Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, United States
  • Toco Yuen Ping Chui
    Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, United States
    Icahn School of Medicine at Mount Sinai, New York, New York, United States
  • Richard B Rosen
    Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, United States
    Icahn School of Medicine at Mount Sinai, New York, New York, United States
  • Rudrani Banik
    Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, United States
    Icahn School of Medicine at Mount Sinai, New York, New York, United States
  • Joshua A Young
    Ophthalmology, New York University, New York, New York, United States
  • Footnotes
    Commercial Relationships   Soshian Sarrafpour, None; Edmund Tsui, None; David Fell, None; Sherief Raouf, None; Nicole Scripsema, None; Sarwar Zahid, None; Sarita Dave, None; Patricia Garcia, None; Toco Chui, None; Richard Rosen, Optovue (C); Rudrani Banik, None; Joshua Young, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 3306. doi:
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      Soshian Sarrafpour, Edmund Tsui, David Fell, Sherief Raouf, Nicole K Scripsema, Sarwar Zahid, Sarita B Dave, Patricia M. Garcia, Toco Yuen Ping Chui, Richard B Rosen, Rudrani Banik, Joshua A Young; Fractal Analysis of Peripapillary Vasculature In Eyes With Papilledema Using Optical Coherence Tomography Angiography. Invest. Ophthalmol. Vis. Sci. 2017;58(8):3306.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To quantify the fractal dimension (FD) of eyes with papilledema as compared with control eyes using Optical Coherence Tomography Angiography (OCTA).

Methods : A retrospective study was performed in 49 eyes with papilledema and 40 control eyes. OCTA images were obtained using the RTVue XR Avanti (Optovue Inc., Fremont, CA, USA). Peripapillary scans of 4.5mm x 4.5mm diameter were obtained. Grayscale OCTA images were standardized and binarized using ImageJ (National Institutes of Health, Bethesda, Maryland, USA). Fractal box-counting analyses were performed using Fractalyse (ThéMA, Besançon Cedex, France). Statistical analysis was performed using one-way analysis of variance with post-hoc Tukey’s multiple comparisons test and two-tailed t-test. Further analyses were performed on papilledema subgroups based on severity (Grade 0, n=12; Grade 1, n=15; Grade 2, n=13; Grade 3, n=5; Grade 4/5, n=4).

Results : The mean FD of all eyes with papilledema (1.677, SD=0.075) was significantly higher (P=0.0021) than control eyes (1.630, SD=0.062). The FD in papilledema subgroups based on severity were Grade 0 (1.707, SD=0.047), Grade 1 (1.675, SD=0.046), Grade 2 (1.674, SD=0.090), Grade 3 (1.610, SD=0.139), Grade 4/5 (1.694, SD=0.060). Analyses between papilledema subgroups demonstrated a significant increase (P<0.05) in FD between Grade 0 papilledema and control eyes. There were no significant differences in pairwise comparisons between other subgroups.

Conclusions : The FD in OCTA of eyes with papilledema was significantly higher compared to control eyes. When analyzed by severity, eyes with Grade 0 papilledema had a higher FD compared to control eyes. Since fractal geometry reflects the branching of the peripapillary microvasculature, an increased FD may correlate with an increase in perfused vessel density as identified by OCTA. Fractal analysis in OCTA has the potential to establish quantitative parameters for peripapillary microvascular pathology in papilledema.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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