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Mindy Wang, Fouad El Sayyad, Hazem Samy; Hodgkin’s Lymphoma Masquerading As Intermediate Uveitis And Bilateral Optic Disc Edema. Invest. Ophthalmol. Vis. Sci. 2017;58(8):3309.
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© ARVO (1962-2015); The Authors (2016-present)
While previous case reports have documented Hodgkin’s lymphoma patients to have granulomatous posterior uveitis, periphlebitis, focal chorioretinitis, and vitritis, we present a case that uniquely presents with bilateral optic disc edema and intermediate uveitis in addition to retinal vasculitis on intravenous fluorescein angiography prior to diagnosis of Hodgkin’s lymphoma.
A 55 year old patient presents with complaints of floaters in the left eye and blurry vision. She was found to have bilateral disc edema and intermediate uveitis in the left eye. She also had retinal vasculitis on intravenous fluorescein angiography. Following a comprehensive work-up, her axillary lymph node excisional biopsy showed classical Hodgkin Lymphoma of mixed cellularity type, diagnosing her with stage 3 Hodgkin’s disease. She was started on the ABVD chemotherapy regimen and has been in remission following its completion. Her intermediate uveitis and bilateral disc edema resolved following chemotherapy treatment.
Hodgkin’s lymphoma can present with intermediate uveitis and bilateral optic disc edema. These ocular findings can resolve following appropriate treatment of Hodgkin’s lymphoma.
It is essential to consider that Hodgkin’s lymphoma may initially present with ocular impairment, and that one should have a high index of suspicion to promptly diagnose and treat the masquerading syndrome. Hodgkin’s lymphoma should be considered in the differential diagnosis when a patient presents with unexplained disc edema with uveitis.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
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