June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Clinicopathologic Correlation of Kaposi Sarcoma involving the Eyelid and Conjunctiva: A Case Series.
Author Affiliations & Notes
  • Jan Paul Ulloa
    Ophthalmology, Bascom Palmer Eye Institute, Miami, Florida, United States
  • Mark P. Ghassibi
    Ophthalmology, Bascom Palmer Eye Institute, Miami, Florida, United States
  • Maria Paula Fernandez
    Ophthalmology, Bascom Palmer Eye Institute, Miami, Florida, United States
  • Sander R Dubovy
    Ophthalmology, Bascom Palmer Eye Institute, Miami, Florida, United States
  • Footnotes
    Commercial Relationships   Jan Ulloa, None; Mark Ghassibi, None; Maria Paula Fernandez, None; Sander Dubovy, None
  • Footnotes
    Support  NIH Center Core Grant P30EY014801, Research to Prevent Blindness Unrestricted Grant, DOD - Grant # W81XWH-09-1-0675 and Grant # W81XWH-13-1-0048 ONOVA, Florida Lions Ocular Pathology Laboratory, Bascom Palmer Eye Institute and University of Miami Miller School of Medicine.
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 3358. doi:
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    • Get Citation

      Jan Paul Ulloa, Mark P. Ghassibi, Maria Paula Fernandez, Sander R Dubovy; Clinicopathologic Correlation of Kaposi Sarcoma involving the Eyelid and Conjunctiva: A Case Series.. Invest. Ophthalmol. Vis. Sci. 2017;58(8):3358.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To report the clinicopathologic findings of 13 cases presenting with Kaposi Sarcoma of the eyelid and conjunctiva.

Methods : In a non-comparative, consecutive case series, the database of the Florida Lions Ocular Pathology Laboratory was searched for surgical specimens diagnosed with Kaposi sarcoma of the eyelid and conjunctiva from the time-period of 1977 to 2016. The histopathologic slides and clinicopathologic features were evaluated.

Results : The diagnosis of Kaposi sarcoma was established by light microscopic examination of formalin fixed, paraffin embedded tissue from the eyelid and conjunctiva of 13 patients (Right = 9, Left = 3 and bilateral = 1). There were 10 males and 3 females. The age of presentation ranged from 25 to 95 years with a mean of 43 years. The lesions involved the conjunctiva in 5 cases, eyelid in 4 cases and cornea in 1 case (clinical information was available for 10 out of the 13 cases, and limited in the 3 remaining cases). HIV-positive patients were identified in 7 out of the 10 cases that had clinical information available. Histopathological examination of the specimens disclosed a tumor composed of vascular channels and slits lined by spindle-shaped cells with plump spindle-shaped and moderately pleomorphic nuclei with scant cytoplasm. Immunohistochemistry disclosed positive staining for CD31 in 13 cases (one weakly positive) and HHV8 in 12 cases. One case was negative for HHV8. No differences in the immunohistochemical and morphological findings of the conjunctival and eyelid lesions were identified.

Conclusions : Herein we illustrate the clinical and pathological findings of 13 cases of Kaposi sarcoma involving the eye and ocular adnexae. The immunohistochemical markers CD31 and HHV8 are helpful adjuncts to morphology in correctly diagnosing the lesions.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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