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Sander R Dubovy, Maria Paula Fernandez, Jan Paul Ulloa, Richard K Lee, Mehrdad Nadji, Norman L. Block, Andrew V. Schally; Somatostatin Receptor-2 Expression in Sebaceous Carcinoma of the Ocular Adnexae. Invest. Ophthalmol. Vis. Sci. 2017;58(8):3362.
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© ARVO (1962-2015); The Authors (2016-present)
Somatostatin receptors are high affinity surface receptors that have shown to be expressed in different organs, tissues and different tumors. Somatostatin Receptor subtype-2 (SSTR2) specifically, has shown to mediate inhibition of cell proliferation and apoptosis. The purpose of this study was to evaluate the expression of SST receptor 2 (SSTR2) in sebaceous carcinoma of the ocular adnexae.
The database at the Florida Lions Ocular Pathology Laboratory was searched for surgical specimens diagnosed with Sebaceous Carcinoma on light microscopic examination from 1990 to 2014. A total of three specimens were randomly retrieved. Immunofluorescence was performed using an antibody for SSTR2 (abcam) to evaluate the expression of this receptor within tumor cells of sebaceous carcinomas. Medical records were reviewed for demographics, clinical presentation, recurrence and treatment. One non-neoplastic sebaceous gland specimen was also retrieved, stained and graded following the aforementioned protocol as a control. IRB/Ethics Committee approval from the University of Miami Miller School of Medicine was obtained for this study.
The diagnosis of sebaceous carcinoma was established by light microscopic examination of formalin fixed, paraffin embedded tissue from the eyelids of three patients. All three patients were female between the ages of 66 and 92. The three cases presented as elevated, vascular lid lesions. On histopathological examination, all demonstrated a tumor composed of foamy, basophilic cells with foci of pleomorphism and brisk mitotic activity. Features of pagetoid spread were identified in the specimens. On immunofluorescence, the three tumors demonstrated a strong expression of SSTR2 within tumor cells and areas of pagetoid spread.
This study demonstrates expression of Somatostatin Receptor-2 within tumor cells of sebaceous carcinomas of the ocular adnexae. The presence of this receptor in sebaceous carcinoma of the eyelid may play a role in the pathophysiology of this tumor. The use of SST analogues may potentially be used as new or adjunctive alternatives for the treatment of sebaceous carcinoma of the ocular adnexae.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
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