June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Correlation of Dark Adaptation with Macular Morphology in Age-related Macular Degeneration
Author Affiliations & Notes
  • Deeba Husain
    Retina Service/Opthal, Massachusetts Eye and Ear Infirmary , Boston, Massachusetts, United States
  • Ines Lains
    Retina Service/Opthal, Massachusetts Eye and Ear Infirmary , Boston, Massachusetts, United States
    Ophthalmology, Universidade de Coimbra, Coimbra, Portugal
  • John B Miller
    Retina Service/Opthal, Massachusetts Eye and Ear Infirmary , Boston, Massachusetts, United States
  • Dongho Park
    Retina Service/Opthal, Massachusetts Eye and Ear Infirmary , Boston, Massachusetts, United States
  • Edem Tsikata
    Glaucoma Service/ Ophthalmology, mass eye and ear, Boston, Massachusetts, United States
  • Samaneh Davoudi
    Retina Service/Opthal, Massachusetts Eye and Ear Infirmary , Boston, Massachusetts, United States
  • Safa Rahmani
    Retina Service/Opthal, Massachusetts Eye and Ear Infirmary , Boston, Massachusetts, United States
  • Jonathan Pierce
    Retina Service/Opthal, Massachusetts Eye and Ear Infirmary , Boston, Massachusetts, United States
  • Rufino Silva
    Ophthalmology, Universidade de Coimbra, Coimbra, Portugal
  • Teresa C Chen
    Glaucoma Service/ Ophthalmology, mass eye and ear, Boston, Massachusetts, United States
  • Ivana K Kim
    Retina Service/Opthal, Massachusetts Eye and Ear Infirmary , Boston, Massachusetts, United States
  • Demetrios G. Vavvas
    Retina Service/Opthal, Massachusetts Eye and Ear Infirmary , Boston, Massachusetts, United States
  • Joan W Miller
    Retina Service/Opthal, Massachusetts Eye and Ear Infirmary , Boston, Massachusetts, United States
  • Footnotes
    Commercial Relationships   Deeba Husain, None; Ines Lains, None; John Miller, None; Dongho Park, None; Edem Tsikata, None; Samaneh Davoudi, None; Safa Rahmani, None; Jonathan Pierce, None; Rufino Silva, None; Teresa Chen, None; Ivana Kim, None; Demetrios Vavvas, None; Joan Miller, Elsevier: Royalties related to textbook (R), Kalvista Pharmaceutical (C), Maculogix Inc (C), ONL Therapeutics (P), ONL Therapeutics (C), Valiant Pharmaceuticals (P), Valiant Pharmaceuticals (R)
  • Footnotes
    Support  This study was financially supported by the Miller Retina Research Fund (Mass. Eye and Ear), the Miller Champalimaud Award (Mass. Eye and Ear), the unrestricted departmental Grant from Research to Prevent Blindness, Inc. New York, and the Portuguese Foundation for Science and Technology/ Harvard Medical School Portugal Program (HMSP-ICJ/006/2013).
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 3402. doi:
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    • Get Citation

      Deeba Husain, Ines Lains, John B Miller, Dongho Park, Edem Tsikata, Samaneh Davoudi, Safa Rahmani, Jonathan Pierce, Rufino Silva, Teresa C Chen, Ivana K Kim, Demetrios G. Vavvas, Joan W Miller; Correlation of Dark Adaptation with Macular Morphology in Age-related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2017;58(8):3402.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : There is increasing evidence that Dark-adaptation (DA) is a useful functional parameter for both detection and severity of AMD. However, the relationship between DA and macular structural changes in AMD has not been well studied. This study aims to evaluate the correlation between DA and morphology using spectral-domain optical coherence tomography (SD-OCT) in the area bleached during the DA testing and in the entire macula

Methods :
Cross-sectional, prospective study, including patients with AMD and a control group (> 50 years) without any vitreoretinal disease. All participants were imaged with color fundus photographs and SD-OCT. Both eyes were tested with the AdaptDx® DA extended protocol (20 minutes). A software program was developed to map the DA testing spot (5 degree superior to fovea) on the OCT B-scans. Two independent graders evaluated the B-scans’ regions included in this spot, as well as in the entire macula, and recorded the presence of several AMD-associated abnormalities. Multilevel mixed effect linear models (accounting for correlated outcomes between 2 eyes) were used for analyses, considering rod-intercept time (RIT) as the outcome

Results : We included 137 eyes (n=77 subjects), 72.3% with AMD and the remaining controls. OCT structural abnormalities were observed within the DA testing spot in 44.5% of the eyes, and in the entire macula in 71.5% . Multivariate analysis revealed that adjusting for age and AMD stage, the presence of any abnormalities within the DA testing spot (ß=4.8, p<0.001), as well as in the macula (ß=2.4, p=0.047), were significantly associated with delayed RITs. In eyes with no structural changes within the DA testing spot (n=76, 55.5%), pathology in the remaining macula was associated with impaired RITs (ß=2.00, p=0.046). The presence of subretinal drusenoid deposits was a consistent predictor of RIT, both if located within the DA spot (ß=3.51, p=0.001), or the macula in general (ß=3.19, p<0.001). Within the testing spot, the presence of ellipsoid disruption, classic drusen and serous PED were also significantly associated with impairments in DA (p≤0.018).

Conclusions : Our results suggest a strong association between retinal anatomy evaluated by OCT and time to dark-adapt. Dark-adaptation is a good indicator of abnormality in the entire macula and not just within the testing spot. Subretinal drusenoid deposits appear to significantly affect dark adaptation.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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