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Marie-Soline LUC, SOT Maxime, Julie Francois, Christophe Goetz, Nadia ouamara, Jean-Marc Perone; Correlation between higher-order aberrations and visual acuity after crosslinking treatment for keratoconus: study of 90 cases. Invest. Ophthalmol. Vis. Sci. 2017;58(8):3500.
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© ARVO (1962-2015); The Authors (2016-present)
The aim of our study is to analyze the correlation between higher order aberrations (HOA) of posterior corneal and visual acuity after crosslinking treatment (CXL) in advanced keratoconus
We performed an observational retrospective study including patients treated with CXL from March 2014 to April 2016. All patients received the same procedure: accelerated-CXL protocol (30 minutes of riboflavin impregnation and 10 minutes of UVA irradiation). The flowing data were assessed preoperatively and at 6 months post CXL: best corrected visual acuity, Kmax, and HOA RMS at 3, 5 and 6 mm. Included patients were splitted into 2 groups; according to their delta visual acuity: in the first group patients with decreased or stabilized visual acuity at 6 months post CXL, in the second group patients with an improvement of visual acuity. The primary endpoint was the delta RMS at 5 mm pupillary diameter. The secondary endpoints were the delta RMS at 3 and 6 mm and the delta Kmax.
Eighty patients (90 eyes) were included: 50 in the decreased or stabilized visual acuity group, 40 in the improved visual acuity group at 6 months. The mean age of the patients was 26 +/- 10 years. The mean visual acuity was 0.33 +/- 0.20 logMAR before CXL and 0.29 +/- 0.19 logMAR post-CXL. The mean RMS at 5 mm was 2.67 +/- 1.3 D eq and 2.71 +/- 1.24 D eq respectively before and after CXL. The delta RMS at 5 mm was 0.01 +/- 0.69 in the improvement visual acuity group and 0.05 +/- 0.64 in the decreased or stabilized visual acuity group. There was no correlation between the visual acuity difference and the HOA (student test p = 0.76). The mean Kmax was 57.08 D and 57.37 D respectively in pre and post-treatment.
The analysis of the 2 groups: decrease or stabilization versus improvement of visual acuity does not therefore reveal any significant difference in the evolution of HOA RMS. It seems therefore that the improvement of the visual acuity post crosslinking is not related to a reduction of the HOA.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
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