June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Corneal topography and aberrometry changes one-year after transepithelial corneal cross-linking using iontophoresis versus standard corneal cross-linking
Author Affiliations & Notes
  • sebastiano serrao
    Cornea and Cataract Department, Fondazione Bietti Roma, Rome, Italy
  • Giuseppe Lombardo
    Cornea and Cataract Department, Fondazione Bietti Roma, Rome, Italy
    Vision Engineering Italy srl, Rome, Italy
  • Daniela Giannini
    Cornea and Cataract Department, Fondazione Bietti Roma, Rome, Italy
  • Marco Lombardo
    Cornea and Cataract Department, Fondazione Bietti Roma, Rome, Italy
  • Footnotes
    Commercial Relationships   sebastiano serrao, None; Giuseppe Lombardo, None; Daniela Giannini, None; Marco Lombardo, None
  • Footnotes
    Support  National and Innovation PON (grant n. 01_00110)
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 3504. doi:
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      sebastiano serrao, Giuseppe Lombardo, Daniela Giannini, Marco Lombardo; Corneal topography and aberrometry changes one-year after transepithelial corneal cross-linking using iontophoresis versus standard corneal cross-linking. Invest. Ophthalmol. Vis. Sci. 2017;58(8):3504.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To assess the 1-year corneal topography and aberrometry changes after transepithelial corneal crosslinking using iontophoresis (T-ionto CL) versus standard crosslinking (standard CL) for the treatment of progressive keratoconus.

Methods : Thirty-four eyes of 25 participants were randomized into T-ionto CL (22 eyes) or standard CL (12 eyes) treatment. T-ionto CL was performed by using an iontophoresis device with dextran-free 0.1% riboflavin solution and by irradiating the cornea with 10 mW/cm2 UV-A device for 9 minutes. Standard CL was performed according to the Dresden protocol. Participants underwent ophthalmic examinations preoperatively and 3-days, 1-week, 1-, 3-, 6- and 12-months after treatment. Changes of corneal shape and optical performance were assessed by analysis of the maximum simulated keratometry (Kmax), central corneal thickness (CCT) and corneal high-order wavefront aberration (from 3rd to 7th orders). Other outcome measures included corrected distance visual acuity (CDVA) and manifest refraction.

Results : Twelve months after T-ionto CL and standard CL, Kmax averagely flattened by 0.52±1.30 D (P=0.06) and 0.82±1.20 D (P=0.04) respectively. No significant average changes were found in corneal high-order wavefront aberration after T-ionto (from 1.94±0.91 µm to 2.00±0.79 µm; P=0.56) and Standard CL (from 2.24±0.77 µm to 2.12±0.85 µm; P=0.16) groups respectively. The average CCT did not significantly change at 12 months from preoperatively in either group (T-ionto CL: +9 µm; P=0.07; Standard CL: -1 µm; P=0.80). The mean change in CDVA was -0.10±0.12 logMAR (P=0.003) and -0.03±0.06 logMAR (P=0.10) after T-ionto CL and standard CL respectively. The manifest spherical equivalent refraction changed averagely by +0.71±1.44 D (P=0.03) and +0.21±0.76 D (P=0.38) respectively. No statistically significant differences were found in the outcome measures between treatments.

Conclusions : At 1 year, there was an average improvement in corneal shape, visual and refractive outcomes after T-ionto CL, though average Kmax flattening was lower than standard CL. No changes were found in the optical performance of the cornea after the operation.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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