June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Save Sight Registries Keratoconus; Tracking the outcomes of corneal cross-linking for Keratoconus from routine clinical practice across Australia and New Zealand
Author Affiliations & Notes
  • Stephanie L Watson
    Ophthalmology, Save Sight Institute, University of Sydney, Bondi Junction, New South Wales, Australia
    Sydney Eye Hospital, Sydney, New South Wales, Australia
  • Elsie Chan
    Centre for Eye Research Australia, Melbourne, Victoria, Australia
    Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia
  • Mark Daniell
    Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia
    Centre for Eye Research Australia, Melbourne, Victoria, Australia
  • Yves Kerdraon
    Ophthalmology, Save Sight Institute, University of Sydney, Bondi Junction, New South Wales, Australia
    Sydney Eye Hospital, Sydney, New South Wales, Australia
  • John Males
    Ophthalmology, Save Sight Institute, University of Sydney, Bondi Junction, New South Wales, Australia
    Sydney Eye Hospital, Sydney, New South Wales, Australia
  • Nigel Morlet
    The University of Western Australia, Perth, Western Australia, Australia
    Sydney Eye Hospital, Sydney, New South Wales, Australia
  • Richard A Mills
    Flinders University, Adelaide, South Australia, Australia
  • Daniel Barthelmes
    Ophthalmology, University Hospital Zurich, Zurich, Switzerland
  • Martina Boesch
    Private Practise, Zurich, Switzerland
  • Amparo Herrera Bond
    Ophthalmology, Save Sight Institute, University of Sydney, Bondi Junction, New South Wales, Australia
  • Amanda Dinh
    Ophthalmology, Save Sight Institute, University of Sydney, Bondi Junction, New South Wales, Australia
  • Vuong Nguyen
    Ophthalmology, Save Sight Institute, University of Sydney, Bondi Junction, New South Wales, Australia
  • Marco Garcia
    Ophthalmology, Save Sight Institute, University of Sydney, Bondi Junction, New South Wales, Australia
  • Mark C Gillies
    Ophthalmology, Save Sight Institute, University of Sydney, Bondi Junction, New South Wales, Australia
  • Footnotes
    Commercial Relationships   Stephanie Watson, None; Elsie Chan, None; Mark Daniell, None; Yves Kerdraon, None; John Males, None; Nigel Morlet, None; Richard Mills, None; Daniel Barthelmes, None; Martina Boesch, None; Amparo Herrera Bond, None; Amanda Dinh, None; Vuong Nguyen, None; Marco Garcia, None; Mark Gillies, None
  • Footnotes
    Support  Ophthalmic Research Institute of Australia grant; Keratoconus Australia grant
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 3523. doi:
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      Stephanie L Watson, Elsie Chan, Mark Daniell, Yves Kerdraon, John Males, Nigel Morlet, Richard A Mills, Daniel Barthelmes, Martina Boesch, Amparo Herrera Bond, Amanda Dinh, Vuong Nguyen, Marco Garcia, Mark C Gillies; Save Sight Registries Keratoconus; Tracking the outcomes of corneal cross-linking for Keratoconus from routine clinical practice across Australia and New Zealand. Invest. Ophthalmol. Vis. Sci. 2017;58(8):3523.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To report the 12 month outcomes of 194 eyes undergoing corneal cross-linking for keratoconus performed in routine clinical practice across Australia and New Zealand.

Methods : Index visit characteristics, such as visual acuity (VA, in Logarithm of the Minimal Angle of Resolution [logMAR] letters), maximum keratometry [Kmax], pachymetry, as well as treatment parameters (epithelial status, riboflavin type, UV duration), outcomes (VA, Kmax, pachymetry) and ocular adverse events were recorded in a prospectively designed electronic database. Index visit characteristics associated with the 12-month VA outcome were identified using mixed effects linear regression.

Results : Mean change in VA in the cohort after 12 months was +3.1 logMAR letters (95% confidence interval [CI]: -0.9, 5.3); Kmax +0.1 D (95% CI: -0.3, 0.5) and pachymetry -14.9 microns (95% CI: -21.0, -8.6). There was no significant difference in change in Kmax (p = 0.649); a significant improvement in VA (p = 0.006) and reduction in pachymetry was found at 12 months (p < 0.001). VA at the index visit was the strongest predictor of the 12-month VA outcomes (p < 0.001). Treatments were epithelial-off (n=178) with UV exposure that was accelerated (n= 118) or according to the Dresden protocol (n=60). Adverse events episodes occurred in 15 eyes and included clinically significant haze (n=22), microbial keratitis (n=1), persistent epithelial defect (n=2), scarring (n=6) and sterile infiltrates (n=2) from a total of 194 eyes within the first 12 months of follow-up.

Conclusions : The Keratoconus module of the Save Sight Registries can facilitate the collection of large amounts of data on corneal cross-linking. The finalised 12 month outcome data has shown that corneal cross-linking can stabilize visual acuity and corneal parameters when used in routine clinical practice.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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