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Masahiro Yamaguchi, Yoshimune Hiratsuka, Toshinari Funaki, Satoru Nakatani, Akira Matsuda, Akira Murakami; Atopic dermatitis as a high risk of recurrent protrusion after penetrating keratoplasty in keratoconic eyes. Invest. Ophthalmol. Vis. Sci. 2017;58(8):3555.
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© ARVO (1962-2015); The Authors (2016-present)
To detect whether if atopic dermatitis affects to recurrent protrusion after keratoplasty in keratoconic eye.
54 eyes of 50 patients who were diagnosed keratoconus, who were received keratoplasty in Juntendo University from 2006 to 2015 and who were conducted suture removal, were included in this study. Criteria for diagnosing protrusion were defined by existence of clinical findings of keratoconus, or corneal topographic change (localized 1D steeping of K-max in the axial power in a year, asymmetric inferior protrusion and inferior thinning). A Cox proportional hazards model was used to determine the influence of donor, recipient and surgical factors on protrusion. Kaplan Meier survival estimates was also conducted the long-term probability of recurrent protrusion.
Recurrent protrusion was detected in 5 eyes of 5 cases (11.1%), occurred in 3.64±3.69 years after surgery. Univariate analysis in a Cox proportional hazards model revealed atopic dermatitis had 14.78 times higher (p<0.01), although recipient age, graft age, graft size, removal duration, and suture type had no statistical difference. Multivariate analysis showed atopic dermatitis had 14.07 times higher risk without effect of suture removal duration. Kaplan Meier survival estimates in 10-year follow up showed 65.0% of patients with atopic dermatitis accompanied protrusion, compared to 2.5% of those who were without atopic dermatitis (p=0.001, Log-rank test).
Our results revealed strong correlation between atopic dermatitis and protrusion after keratoplasty in keratoconic eyes.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
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