June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Multimodal Imaging of Retinal Vein Occlusions using Optical Coherence Tomography Angiography and En Face Optical Coherence Tomography
Author Affiliations & Notes
  • Michael J. Heiferman
    Department of Ophthalmology, Northwestern University, Chicago, Illinois, United States
  • Peter L Nesper
    Department of Ophthalmology, Northwestern University, Chicago, Illinois, United States
  • Manjot Gill
    Department of Ophthalmology, Northwestern University, Chicago, Illinois, United States
  • Amani A Fawzi
    Department of Ophthalmology, Northwestern University, Chicago, Illinois, United States
  • Footnotes
    Commercial Relationships   Michael Heiferman, None; Peter Nesper, None; Manjot Gill, None; Amani Fawzi, None
  • Footnotes
    Support  Research to Prevent Blindness to Northwestern University
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 3677. doi:
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      Michael J. Heiferman, Peter L Nesper, Manjot Gill, Amani A Fawzi; Multimodal Imaging of Retinal Vein Occlusions using Optical Coherence Tomography Angiography and En Face Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2017;58(8):3677.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Optical coherence tomography angiography (OCTA) offers a novel method to image retinal vascular diseases including retinal vein occlusions. We performed a retrospective clinical study to identify and compare areas of non-perfusion seen on OCTA to the vasculature visualized on en face spectral domain optical coherence tomography (en face OCT).

Methods : This study included a total of 21 eyes, 11 eyes with central retinal vein occlusions and 10 eyes with branch retinal vein occlusions. A masked observer examined the en face OCT, OCTA and fluorescein angiography (FA). We identified areas with vessels seen on en face OCT that were non-perfused on OCTA and correlated these areas with findings at the corresponding location in OCT scans and on FA.

Results : Of the eyes studied, 17 had discordance between the vasculature seen on OCTA and en face SD-OCT. Of the eyes with CRVO, 8 had visible vessels on SD-OCT in areas of non-perfusion on OCTA while the remaining 3 cases of CRVO had no visible vessels on en face OCT in areas of non-perfusion on OCTA. Nine of the ten cases of BRVO similarly had persistent vessels on en face OCT in areas which showed non-perfusion on OCTA.

Conclusions : Our findings indicate a wide range of variations in the abnormalities on OCTA and en face OCT in non-perfused vessels. Comparison of these discrepancies to FA confirm that non-perfusion on OCTA corresponds to FA non-perfusion. Our findings demonstrate that OCTA precisely delineates areas of non-perfusion. Clinicians should consider multimodality imaging when evaluating BRVO and CRVO.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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