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Hyoung Won Bae, Eun Min Kang, Gong Je Seong, Chan Yun Kim; Association between Open-Angle Glaucoma and Hypothyroidism: A Meta-Analysis. Invest. Ophthalmol. Vis. Sci. 2017;58(8):3714.
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To evaluate whether a significant association exists between hypothyroidism and open-angle glaucoma (OAG) by performing a meta-analysis of previous studies.
A comprehensive search for articels published before 31 December 2015 was performed using PubMed, Embase, and reference lists. The pooled odds ratio (OR) was calculated using the fixed-and random-effects models. Subgroup analysises were also conducted, and publication bias was assessed using a funnel plot and Egger’s regression test.
In total, 8 studies with 353,461 indivisuals met the inclusion criteria. The pooled OR of four population - based studies was 1.26 (95% CI: 0.83–1.92) using the random-effects model. No significant association was also identified in a meta-analysis of three hospital – based studies using random – effects model, which showed a pooled OR of 2.02 (95% CI: 0.76–5.41). For subgroup analyses, using the random-effects model, the pooled OR for untreated hypothyroidism and treated hypothyroidism were 1.05 (95% CI: 0.62–1.79) and 1.23 (95% CI: 0.82–1.83), respectively. No publication bias was detected in either analysis.
The present meta-analysis showed a lack of an association between hypothyroidism and OAG. We also found that the development of OAG was not affected by either untreated or treated hypothyroidism.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
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