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Jae Yeun Lee, Ko Un Shin, Joon Mo Kim; Relationship between renal function and disc hemorrhage. Invest. Ophthalmol. Vis. Sci. 2017;58(8):3715.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate the relationship between renal function and disc hemorrhage(DH) in South Korean population.
This retrospective cross-sectional study included subjects who underwent screening at Kangbuk Samsung Hospital Health Screening Center between August 2012 and July 2013.Subjects underwent a physical examination and provided samples for laboratory analysis for renal function. The estimated glomerular filtration rate (eGFR) was calculated from serum creatinine concentrations using the Modification of Diet in Renal Disease equation. All fundus photographs were first reviewed by two ophthalmologists and then by two glaucoma specialists and one retina specialist to determine the presence of DHs.
Fundus photographs were available for 164,029/168,044 (97.61%) subjects 20 years and older. The prevalence of DH was 226/164,029 (0.14%; 95% confidence interval, 0.12 to 0.16) per subject. DH group had a higher male preponderance, older and a higher IOP, higher blood pressure, higher pulse pressure, higher fasting blood glucose, higher HbA1c, higher serum creatinine, higher total cholesterol, higher LDL cholesterol and lower eGFR than non-DH group.In multiple logistic regression models were adjusted by age, sex, intraocular pressure, systolic blood pressure, diastolic blood pressure, pulse pressure, fasting blood glucose, Hemoglobin A1c, total cholesterol, LDL cholesterol, diabetes mellitus, hypertension, hyperlipidemia.Then lower eGFR (<90 ml/min/1.73 m2) was significantly associated with DH (aOR, 1.43; 95% CI, 1.06-1.94). After controlling for confounders, there was a significant trend between decreased eGFR and the prevalence of DH (p for trend = 0.005, logistic regression analysis).
Our results suggest that low eGFR levels are independently associated with development of DH.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
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