June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
The Ocular Hypertension Treatment Study Calculator in an African American Population
Author Affiliations & Notes
  • PRITHVI SANKAR
    Scheie Eye Institute, Philadelphia, Pennsylvania, United States
  • Qi J Cui
    Scheie Eye Institute, Philadelphia, Pennsylvania, United States
  • Carly Breen
    Scheie Eye Institute, Philadelphia, Pennsylvania, United States
  • Frank Woo
    Scheie Eye Institute, Philadelphia, Pennsylvania, United States
  • Fred Vilson
    Scheie Eye Institute, Philadelphia, Pennsylvania, United States
  • Alexis Williams
    Scheie Eye Institute, Philadelphia, Pennsylvania, United States
  • Dionne May
    Scheie Eye Institute, Philadelphia, Pennsylvania, United States
  • Athena Petrides
    Scheie Eye Institute, Philadelphia, Pennsylvania, United States
  • Roy Lee
    Scheie Eye Institute, Philadelphia, Pennsylvania, United States
  • Eydie G Miller-Ellis
    Scheie Eye Institute, Philadelphia, Pennsylvania, United States
  • Amanda Lehman
    Scheie Eye Institute, Philadelphia, Pennsylvania, United States
  • Victoria Addis
    Scheie Eye Institute, Philadelphia, Pennsylvania, United States
  • Joan M O'Brien
    Scheie Eye Institute, Philadelphia, Pennsylvania, United States
  • Footnotes
    Commercial Relationships   PRITHVI SANKAR, None; Qi Cui, None; Carly Breen, None; Frank Woo, None; Fred Vilson, None; Alexis Williams, None; Dionne May, None; Athena Petrides, None; Roy Lee, None; Eydie Miller-Ellis, None; Amanda Lehman, None; Victoria Addis, None; Joan O'Brien, None
  • Footnotes
    Support  This work was supported by the National Eye Institute, Bethesda, Maryland (grant #1RO1EY023557-01) and the Department of Ophthalmology at the Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. Funds also come from the F.M. Kirby Foundation, Research to Prevent Blindness, The Paul and Evanina Bell Mackall Foundation Trust, and the National Eye Institute, National Institutes of Health, Department of Health and Human Services, under eyeGENETM and contract Nos. HHSN260220700001C and HHSN263201200001C.
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 3724. doi:
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      PRITHVI SANKAR, Qi J Cui, Carly Breen, Frank Woo, Fred Vilson, Alexis Williams, Dionne May, Athena Petrides, Roy Lee, Eydie G Miller-Ellis, Amanda Lehman, Victoria Addis, Joan M O'Brien; The Ocular Hypertension Treatment Study Calculator in an African American Population. Invest. Ophthalmol. Vis. Sci. 2017;58(8):3724.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : The Ocular Hypertension Treatment Study (OHTS) developed a widely available calculator to ascertain an individual's five-year risk of developing primary open-angle glaucoma (POAG). The purpose of this study was to determine whether the OHTS calculator can be applied to an exclusively African American population.

Methods : An electronic chart review was conducted on patients in the Primary Open-Angle African American Glaucoma Genetics (POAAGG) study. Glaucoma suspects with ocular hypertension in one or both eyes with more than five years of follow-up within the POAAGG study (funded April 2014) were considered for inclusion. Age, sex, central corneal thickness, highest tonometry reading, visual field data, and optic nerve data were obtained.

Results : Nine subjects, five female and four male, were studied as an initial pilot. Average age was 67.1 ± 9.0 years (mean ± standard deviation). Four of the nine subjects converted to POAG within the five-year timeline. Of the four who converted, one had an estimated risk of ≥ 33% and converted after one month; two had a risk score of 20% and converted after three months; and one had a risk of 15% and converted after 51 months. Average time for conversion to a diagnosis of POAG was 14.5 ± 24.4 months. Of the five subjects who did not convert to POAG within the five-year timeline, the risk calculator score ranged between 10-20%.

Conclusions : The OHTS calculator risk assessment varied for African American subjects who converted to glaucoma and overlapped for subjects who did not convert within the five-year timeline. This analysis will be expanded to include more POAAGG subjects and other African American subjects outside of the POAAGG study.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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