June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Brachial artery flow-mediated vasodilation, carotid artery intimal medial thickness and carotid artery plaques in hypertensive patients with NAION
Author Affiliations & Notes
  • Wenhui Zhu
    Ophthalmology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
    Zhongshan Ophthalmic Center, Guangzhou, China
  • Tingting Chen
    Zhongshan Ophthalmic Center, Guangzhou, China
  • Ling Jin
    Zhongshan Ophthalmic Center, Guangzhou, China
  • Haoyu Wang
    School of Medicine, Stopford Building, University of Manchester, Manchester, United Kingdom
  • Nathan G Congdon
    Zhongshan Ophthalmic Center, Guangzhou, China
  • Footnotes
    Commercial Relationships   Wenhui Zhu, None; Tingting Chen, None; Ling Jin, None; Haoyu Wang , None; Nathan Congdon, None
  • Footnotes
    Support  The Department of Science and Technology of Guangdong Province Grant 2014A020212578
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 3859. doi:
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      Wenhui Zhu, Tingting Chen, Ling Jin, Haoyu Wang, Nathan G Congdon; Brachial artery flow-mediated vasodilation, carotid artery intimal medial thickness and carotid artery plaques in hypertensive patients with NAION. Invest. Ophthalmol. Vis. Sci. 2017;58(8):3859.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : The exact causal mechanism of non-arteritic anterior ischaemic optic neuropathy (NAION) still remains unclear, especially the relationship between NAION and systemic diseases. The purpose of this study was to evaluate systemic endothelial function and carotid artery atherosclerosis in middle-aged and elderly hypertension patients with NAION by high-resolution ultrasonography.

Methods : This case-control study included 192 patients, in which, 48 of them were NAION patients with systemic hypertension, 46 of them were hypertension patients without NAION and 98 of them were normal control participants. Brachial artery flow-mediated vasodilation (FMD), intima-media thickness of the common carotid artery (C-IMT) and carotid artery plaque of common carotid arteries were measured by ultrasound which were performed and reported by the same expert operator. Traditional cardio-vascular risk factors were measured.

Results : By multiple regression analysis, lower FMD (OR, 0.78; 95% CI, 0.61-0.98, P=0.04), thicker C-IMT (OR, 173.2; 95% CI, 14.4 - >999, P<0.001), the carotid artery plaques of grade 1 (OR, 4.06; 95% CI, 1.40-11.8, P=0.01) and grade 2 (OR, 10.8; 95% CI, 2.46-47.5, P=0.002) were associated with NAION in hypertensive patients. C-IMT was 75% sensitive and 74% specific in predicting NAION in the affected side (cut-off point of 1.07); whereas, FMD was 52% sensitive and 81% specific in predicting NAION (cut-off point of 4.21). Furthermore, carotid artery plaques score (CPS) (AUC 0.75, 95% CI: 0.68-0.83) was 73% sensitive and 76% specific in predicting NAION (cut-off point of 2).

Conclusions : FMD, C-IMT and carotid artery plaque were associated with NAION in hypertensive patients with NAION, suggesting that NAION might be associated with endothelial dysfunction as well as carotid artery atherosclerosis. C-IMT, FMD and CPS could also be used as non-invasive surrogate markers in predicting the risk of developing NAION in hypertensive patients.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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