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Hadeel AL Chalabi, Ehsan Ghasemian, Aleksandra Inic-Kanada, Elisabeth Stein, Nadine Schuerer, Talin Barisani-Asenbauer; Tear concentration of neuropeptides in subjects with trachomatous trichiasis. Invest. Ophthalmol. Vis. Sci. 2017;58(8):3892.
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© ARVO (1962-2015); The Authors (2016-present)
Trachoma is the leading cause of infectious blindness worldwide but the immunopathogenesis of scarring disease is not well understood. Bidirectional communication between the immune system and nervous system by releasing and binding of certain neurotransmitters might play a role in the fibrosis process. In this study, we aimed to evaluate tear concentrations of Substance P (SP), Neuropeptide Y (NPY) and Somatostatin (SS) in patients with trachomatous trichiasis (TT).
A comparative clinical investigation on 20 subjects with TT and 20 sex- and age-matched controls was performed. The concentrations of neuropeptides SP, NPY and SS in tears were measured using ELISA.
NPY levels in tears (7.78 ± 2.84 ng/ml) were significantly higher (p<0.05) in TT subjects compared to controls (5.97 ± 1.73). No significant differences in tear levels of SP and SS were observed between TT subjects and controls.
Locally released NPY may participate in the development of the fibrosis process. Further studies are needed to clarify the specific role of NPY.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
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