June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Tear concentration of neuropeptides in subjects with trachomatous trichiasis
Author Affiliations & Notes
  • Hadeel AL Chalabi
    OCUVAC – Center of Ocular Inflammation and Infection; Laura Bassi Centers of Expertise, Center for Pathophysiology, Infectiology and Immunology; Medical University of Vienna, Vienna, Austria
  • Ehsan Ghasemian
    OCUVAC – Center of Ocular Inflammation and Infection; Laura Bassi Centers of Expertise, Center for Pathophysiology, Infectiology and Immunology; Medical University of Vienna, Vienna, Austria
  • Aleksandra Inic-Kanada
    OCUVAC – Center of Ocular Inflammation and Infection; Laura Bassi Centers of Expertise, Center for Pathophysiology, Infectiology and Immunology; Medical University of Vienna, Vienna, Austria
  • Elisabeth Stein
    OCUVAC – Center of Ocular Inflammation and Infection; Laura Bassi Centers of Expertise, Center for Pathophysiology, Infectiology and Immunology; Medical University of Vienna, Vienna, Austria
  • Nadine Schuerer
    OCUVAC – Center of Ocular Inflammation and Infection; Laura Bassi Centers of Expertise, Center for Pathophysiology, Infectiology and Immunology; Medical University of Vienna, Vienna, Austria
  • Talin Barisani-Asenbauer
    OCUVAC – Center of Ocular Inflammation and Infection; Laura Bassi Centers of Expertise, Center for Pathophysiology, Infectiology and Immunology; Medical University of Vienna, Vienna, Austria
  • Footnotes
    Commercial Relationships   Hadeel AL Chalabi, None; Ehsan Ghasemian, None; Aleksandra Inic-Kanada, None; Elisabeth Stein, None; Nadine Schuerer, None; Talin Barisani-Asenbauer, None
  • Footnotes
    Support  Austrian Research Promotion Agency (FFG project number 822768).
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 3892. doi:
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      Hadeel AL Chalabi, Ehsan Ghasemian, Aleksandra Inic-Kanada, Elisabeth Stein, Nadine Schuerer, Talin Barisani-Asenbauer; Tear concentration of neuropeptides in subjects with trachomatous trichiasis. Invest. Ophthalmol. Vis. Sci. 2017;58(8):3892.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Trachoma is the leading cause of infectious blindness worldwide but the immunopathogenesis of scarring disease is not well understood. Bidirectional communication between the immune system and nervous system by releasing and binding of certain neurotransmitters might play a role in the fibrosis process. In this study, we aimed to evaluate tear concentrations of Substance P (SP), Neuropeptide Y (NPY) and Somatostatin (SS) in patients with trachomatous trichiasis (TT).

Methods : A comparative clinical investigation on 20 subjects with TT and 20 sex- and age-matched controls was performed. The concentrations of neuropeptides SP, NPY and SS in tears were measured using ELISA.

Results : NPY levels in tears (7.78 ± 2.84 ng/ml) were significantly higher (p<0.05) in TT subjects compared to controls (5.97 ± 1.73). No significant differences in tear levels of SP and SS were observed between TT subjects and controls.

Conclusions : Locally released NPY may participate in the development of the fibrosis process. Further studies are needed to clarify the specific role of NPY.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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