June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Strong influence of ocular, cardiovascular, anthropometric and lifestyle parameters on retinal nerve fiber layer thickness detected in the Gutenberg Health Study (GHS)
Author Affiliations & Notes
  • Stefan Nickels
    Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany
  • Julia Lamparter
    Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany
    Private practice “AugenZentrum Leinfelden”, Leinfelden-Echterdingen, Germany
  • Irene Schmidtmann
    Institute for Medical Biostatistics, Epidemiology and Informatics, University Medical Center Mainz, Mainz, Germany
  • Alexander Karl-Georg Schuster
    Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany
  • Philipp S Wild
    Preventive Cardiology and Preventive Medicine, University Medical Center Mainz, Mainz, Germany
    University Medical Center Mainz, Center for Thrombosis and Hemostasis (CTH), Mainz, Germany
  • Harald Binder
    Institute for Medical Biostatistics, Epidemiology and Informatics, University Medical Center Mainz, Mainz, Germany
  • Karl J Lackner
    Institute for Clinical Chemistry and Laboratory Medicine, University Medical Center Mainz, Mainz, Germany
  • Manfred E Beutel
    Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Mainz, Mainz, Germany
  • Thomas Münzel
    Center for Cardiology I, University Medical Center Mainz, Mainz, Germany
  • Norbert Pfeiffer
    Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany
  • Esther M Hoffmann
    Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany
  • Footnotes
    Commercial Relationships   Stefan Nickels, None; Julia Lamparter, None; Irene Schmidtmann, None; Alexander Schuster, None; Philipp Wild, None; Harald Binder, None; Karl Lackner, None; Manfred Beutel, None; Thomas Münzel, None; Norbert Pfeiffer, None; Esther Hoffmann, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 3986. doi:
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    • Get Citation

      Stefan Nickels, Julia Lamparter, Irene Schmidtmann, Alexander Karl-Georg Schuster, Philipp S Wild, Harald Binder, Karl J Lackner, Manfred E Beutel, Thomas Münzel, Norbert Pfeiffer, Esther M Hoffmann; Strong influence of ocular, cardiovascular, anthropometric and lifestyle parameters on retinal nerve fiber layer thickness detected in the Gutenberg Health Study (GHS)
      . Invest. Ophthalmol. Vis. Sci. 2017;58(8):3986.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Glaucoma is a neurodegenerative disease that leads to thinning of the retinal nerve fiber layer (RNFL). We aim to evaluate the influence of ocular, cardiovascular, anthropometric and lifestyle factors on peripapillary RNFL thickness (RNFLT) in the Gutenberg Health Study.

Methods : The Gutenberg Health Study (GHS) is a population-based, prospective, observational, interdisciplinary cohort study with a total of 15,010 participants. In this study, global peripapillary RNFLT was measured in a subgroup of 1973 subjects (3224 eyes) using spectral-domain optical coherence tomography (SD-OCT, Heidelberg Engineering). The influence of age, sex, axial length (Lenstar LS900, Haag-Streit), spherical equivalent (auto-refraction, HARK 599, Carl Zeiss), intra-ocular pressure (non-contact tonometry, NT-2000, Nidek), central corneal thickness (Pentacam HR, Oculus), self-reported glaucoma, systemic hypertension, diabetes mellitus, and self-reported sleep apnea, tinnitus, alcohol intake (dichotomized >10g/d for women and >20g/d for men ) on RNFLT was analyzed using Pearson correlation and multivariable linear regression.

Results : In the univariate analysis, highest correlations with RNFLT were found for axial length (r=-0.27), spherical equivalent (r=0.24), and self-reported glaucoma (r=-0.15). Other significant correlations were age, sex, intraocular pressure, systemic hypertension and systolic blood pressure, previous eye surgery, cholesterol, homocysteine, coronary artery disease, myocardial infarction, sleep apnea, diabetes mellitus and alcohol intake. The multivariable linear regression showed a significant relationship between RNFLT and age (reduction of 4-8 µm RNFLT per decade , p=0.0001), spherical equivalent (1.33 µm per diopter, p<0.0001), axial length (-1.29 µm per mm, p<0.0001), glaucoma (-7.69 µm, p<0.0001), tinnitus (1.38 µm, p=0.04), sleep apnea (-17.0 µm, p=0.047), homocysteine (-0.10 µm per mmol/L, p=0.05) and alcohol intake (-1.46 µm, p=0.02).

Conclusions : The strong influence of age and ocular parameters on RNFLT must be considered when defining normal values and evaluating peripapillary RNFLT. Whether alcohol intake is a risk factor for RNFLT decrease needs to be confirmed by the analysis of longitudinal data.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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