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geng wang; Asymmetry of optic nerve head parameters measured by confocal scanning laser ophthalmoscopy in myopic anisometropic eyes. Invest. Ophthalmol. Vis. Sci. 2017;58(8):4006.
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© ARVO (1962-2015); The Authors (2016-present)
Assessing the asymmetry of optic nerve head in both eyes is important for the diagnosis of glaucoma. Studies have shown that hyperopic anisometropia is associated with a remarkable interocular difference in optic nerve head morphology. Myopia is a worldwide common ocular disorder, which can increase the risk of primary open angle glaucoma (POAG) by two to three folds. The aim of the study is to evaluate the asymmetry of optic nerve head parameters measured by confocal scanning laser ophthalmoscopy (CSLO) in myopic anisometropic eyes.
Forty-four eyes of 22 myopic anisometropic subjects, defined as the difference of spherical equivalent (SE) between both eyes is ≥1.5D, were recruited and underwent eye examinations and investigations to rule out glaucoma and other eye diseases. The optic nerve heads were measured using the Heidelberg Retina Tomograph II (Heidelberg Engineering, GmBH, Heidelberg, Germany). Differences in optic nerve head parameters between more myopic eyes and fellow eyes were evaluated using the paired-sample t test.
The mean SE was -4.37D (95% CI -4.36 to -5.05, range: 0.00 to -8.50). The mean SE difference was 2.33D (95% CI 2.05 to 2.62, range: 1.5 to 3.88). The vertical cup disk ratio (P=0.039), cup disc area ratio (P=0.029) and rim disc area ratio (P=0.029) were significantly smaller in more myopic eye. No significant difference was found in vertical cup disk ratio (P=0.088) and linear cup disk ratio (P=0.068) between both eyes.
The vertical cup disk ratio, cup disc area ratio and rim disc area ratio were significantly smaller in the more myopic eyes in myopic anisometropic subjects. Marginal significant difference was found in vertical cup disk ratio and linear cup disk ratio between both eyes in myopic anisometropic subjects. Further studies with larger samples are needed to confirm the asymmetry of optic nerve head in myopic anisometropic eyes.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
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