June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Optical Subretinal Fluid Density as a Prognostic Biomarker for Macula Off Rhegmatogenous Retinal Detachment
Author Affiliations & Notes
  • Brandon Kuley
    Sidney Kimmel Medical College, Philadelphia, Pennsylvania, United States
  • Thomas Jenkins
    Wills Eye Hospital, Philadelphia, Pennsylvania, United States
  • Murtaza K Adam
    Wills Eye Hospital, Philadelphia, Pennsylvania, United States
    Mid Atlantic Retina, Plymouth Meeting, Pennsylvania, United States
  • Ehsan Rahimy
    Palo Alto Medical Foundation, Palo Alto, California, United States
  • Jason Hsu
    Wills Eye Hospital, Philadelphia, Pennsylvania, United States
    Mid Atlantic Retina, Plymouth Meeting, Pennsylvania, United States
  • Sunir Garg
    Wills Eye Hospital, Philadelphia, Pennsylvania, United States
    Mid Atlantic Retina, Plymouth Meeting, Pennsylvania, United States
  • Footnotes
    Commercial Relationships   Brandon Kuley, None; Thomas Jenkins, None; Murtaza Adam, None; Ehsan Rahimy, None; Jason Hsu, None; Sunir Garg, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 4148. doi:
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      Brandon Kuley, Thomas Jenkins, Murtaza K Adam, Ehsan Rahimy, Jason Hsu, Sunir Garg; Optical Subretinal Fluid Density as a Prognostic Biomarker for Macula Off Rhegmatogenous Retinal Detachment. Invest. Ophthalmol. Vis. Sci. 2017;58(8):4148.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Quantitative optical density (OD) measurement of sub- or intraretinal fluid on optical coherence tomography (OCT) is a novel imaging biomarker that has been reported to differentiate macular diseases and may have prognostic significance. Patients with macula involving rhegmatogenous retinal detachment (RRD) typically have an uncertain visual prognosis. We evaluated the correlation of subretinal OD and visual outcomes following macula off RRD repair.

Methods : A retrospective, multicenter observational study of patients with primary macula involving RRD who had spectral domain OCT (SD-OCT) on presentation and after subsequent surgical repair. Patients with history of other ocular disease, redetachment following repair, and poor-quality OCT scan were excluded. OD values of the vitreous and subretinal fluid (SRF) were obtained using ImageJ (National Institutes of Health) and an OD ratio (ODR) of SRF to vitreous was calculated. Patients were divided into 3 groups based on reported duration of RRD symptoms: acute (<1 week), subacute (1 week -1 month), and chronic (>1 month).

Results : Thirty-nine eyes of 39 patients met inclusion criteria with an average age of 58 years (range 25-85). Between the 3 groups, patients did not differ in age, presenting visual acuity (VA), extent of retinal detachment in clock hours, or subfoveal SRF height (all p>.05). Mean ODRs for the acute (0.63±0.32), subacute (0.63±0.33), and chronic (0.56±0.22) groups were not significantly different (p=0.09). ODR and SRF height did not correlate with post-operative VA (p=0.09).

Conclusions : ODRs of SRF to vitreous did not correlate with reported duration of RRD symptoms or post-operative VA in this retrospective study. Further prospective studies should be undertaken to better evaluate OD of SRF as a prognostic biomarker for macula involving RRDs.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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