June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Efficacy of two different thiol-modified crosslinked hyaluronate formulations compared to silicone oil in a model of retinal detachment
Author Affiliations & Notes
  • Martin Stephan Spitzer
    Ophthalmology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
  • Nele Schneider
    Ophthalmology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
  • Jose Hurst
    Ophthalmology, University of Tuebingen, Tuebingen, Germany
  • Christine Hohenadl
    Croma Pharma, Leobendorf, Austria
  • Kai Januschowski
    Ophthalmology, University of Tuebingen, Tuebingen, Germany
  • Sven Schnichels
    Ophthalmology, University of Tuebingen, Tuebingen, Germany
  • Footnotes
    Commercial Relationships   Martin Spitzer, Croma Pharma (F); Nele Schneider, Croma Pharma (F); Jose Hurst, None; Christine Hohenadl, Croma Pharma (E); Kai Januschowski, None; Sven Schnichels, Croma Pharma (F)
  • Footnotes
    Support  Croma Research Grant
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 4174. doi:
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      Martin Stephan Spitzer, Nele Schneider, Jose Hurst, Christine Hohenadl, Kai Januschowski, Sven Schnichels; Efficacy of two different thiol-modified crosslinked hyaluronate formulations compared to silicone oil in a model of retinal detachment
      . Invest. Ophthalmol. Vis. Sci. 2017;58(8):4174.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate the efficacy of two novel artificial vitreous body substitutes (VBS) consisting of highly biocompatible thiolated cross-linked hyaluronic acid (HA)-based hydrogels in comparison to silicone oil in a model of retinal detachment.

Methods : Pars plana vitrectomy (23G) was performed in the right eye of 24 pigmented rabbits. Retinal detachment of two quadrants was induced by creating a small retinotomy near the vascular arcade and injecting balanced salt solution (BSS) subretinally. The retina was reattached by injecting air, which was followed by increasing the infusion pressure, and the retinal tear was treated by endolaser photocoagulation. At the end of the procedure, the eye was filled either with 5000-cs silicone oil (after fluid air exchange) or the respective hydrogel (with two different viscosities). Follow-up examination included slit lamp examination, funduscopy, intraocular pressure measurements (IOP), optical coherence tomography (OCT) and electroretinogram (ERG) measurements. After a maximum follow-up of four weeks both eyes were removed, examined macroscopically, photographed, and prepared for histology.

Results : Of the eight rabbits that received silicone oil, seven (87.5%) developed a recurrent retinal detachment with pronounced proliferative vitreoretinopathy within the first two weeks after surgery. In contrast, in the hydrogel treated eyes, the retina stayed attached in the majority of the cases (73.3%). IOP and retinal morphology were normal as long as the retina remained re-attached.

Conclusions : In this model of retinal detachment, both thiolated crosslinked hyaluronate hydrogels showed superior efficacy when compared to silicone oil. These hydrogels have a promising potential as novel vitreous body substitutes.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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