June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Chronic Implantation of a wide-field dual-array suprachoroidal–transretinal stimulation (STS) prosthesis in dogs
Author Affiliations & Notes
  • Takeshi Morimoto
    Applied Visual Science, Osaka Univ Graduate Sch of Med, Suita, Japan
  • Hiroyuki Kanda
    Applied Visual Science, Osaka Univ Graduate Sch of Med, Suita, Japan
  • Takao Endo
    Ophthatmology, Osaka University Graduate School of Medicine, Suita, Japan
  • Kohji Nishida
    Ophthatmology, Osaka University Graduate School of Medicine, Suita, Japan
  • Takashi Fujikado
    Applied Visual Science, Osaka Univ Graduate Sch of Med, Suita, Japan
  • Footnotes
    Commercial Relationships   Takeshi Morimoto, None; Hiroyuki Kanda, NIDEK Co.Ltd (F); Takao Endo, None; Kohji Nishida, None; Takashi Fujikado, NIDEK Co.Ltd (F)
  • Footnotes
    Support  JSPS KAKENHI Grant Number JP26462684
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 4181. doi:
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      Takeshi Morimoto, Hiroyuki Kanda, Takao Endo, Kohji Nishida, Takashi Fujikado; Chronic Implantation of a wide-field dual-array suprachoroidal–transretinal stimulation (STS) prosthesis in dogs. Invest. Ophthalmol. Vis. Sci. 2017;58(8):4181.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate the feasibility of implanting a wide-field dual-array suprachoroidal-transretinal stimulation (STS) prosthesis in dogs and to determine its biocompatibility and stability.

Methods : The STS prosthesis system consisted of two arrays of 25 electrodes each and an extraocular microstimulator. The arrays were implanted into a scleral pocket of each of four healthy beagle dogs. Color fundus photography, fluorescein angiography, electroretinography, and functional testing of the STS system were performed postoperatively. The dogs were euthanatized from 3 to 6 months after the implantation, and the retinas were evaluated histologically.

Results : All the prostheses were successfully implanted without complications, and no serious complications occurred during the postoperative period. The fixation of the implant was stable throughout the experimental period. Fundus photographs and OCT, FA revealed no serious damage in the retina and choroid around the arrays. Histologic evaluations showed good preservation of the retina over the electrode array.

Conclusions : Implantation of a wide-field dual-array STS retinal prosthesis into a scleral pocket of animals is surgically feasible and can be performed without significant damage to the retina or the animal. The biocompatibility and stability of the system were good for the observation period.
These findings indicate that it might be possible to implant more STS electrode arrays to cover a larger area of the retina to activate a larger visual field.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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